For research use only. Not for therapeutic Use.
MeOSuc-AAPF-CMK(CAT: I040395) (methoxysuccinyl-alanine-alanine-proline-phenylalanine-chloromethyl ketone) is a synthetic tetrapeptide-based irreversible inhibitor that specifically targets chymotrypsin-like proteases, particularly caspase-like proteasome subunits and serine proteases such as cathepsin G. The peptide sequence AAPF confers selectivity, while the CMK (chloromethyl ketone) warhead covalently modifies active site residues, leading to permanent enzyme inactivation. This inhibitor is widely used in studies of proteasome function, apoptosis, inflammation, and immune signaling, making it an essential tool in biochemical and cellular research. MeOSuc-AAPF-CMK is supplied at high purity and is ideal for probing protease activity in preclinical and mechanistic investigations.
| CAS Number | 137259-05-3 |
| Synonyms | methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate |
| Molecular Formula | C26H35ClN4O7 |
| Purity | ≥95% |
| IUPAC Name | methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate |
| InChI | InChI=1S/C26H35ClN4O7/c1-16(28-22(33)11-12-23(34)38-3)24(35)29-17(2)26(37)31-13-7-10-20(31)25(36)30-19(21(32)15-27)14-18-8-5-4-6-9-18/h4-6,8-9,16-17,19-20H,7,10-15H2,1-3H3,(H,28,33)(H,29,35)(H,30,36)/t16-,17-,19-,20-/m0/s1 |
| InChIKey | JAUSHYPNDJVUHD-ZULIPRJHSA-N |
| SMILES | CC(C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)CCl)NC(=O)CCC(=O)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
