Faropenem sodium

• CAT Number: A001236
• CAS Number: 122547-49-3
• Molecular Formula: C12H14NO5S Na
• Molecular Weight: 335.31
• Purity: ≥95%
• Storage: Store at RT

Faropenem sodium is a broad spectrum beta-lactam antibiotic belonging to the penem antibiotic class. Faropenem sodium is freely soluble in water (>20mg/mL).
β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like other antibiotics in the penem class, faropenem sodium is highly resistant to β-lactamases and some extended spectrum β-lactamases (ESBLs).

Reference

Milazzo, I. /Faropenem, a New Oral Penem: Antibacterial Activity against Selected Anaerobic and Fastidious Periodontal Isolates./ Journal of Antimicrobial Chemotherapy