Memantine Hydrochloride

• CAT Number: A000392
• CAS Number: 41100-52-1
• Molecular Formula: C12H22ClN
• Molecular Weight: 215.81
• Purity: ≥95%
• Synonyms: 41100-52-1; Memantine HCL; 3,5-dimethyladamantan-1-amine hydrochloride; 3,5-Dimethyl-1-adamantanamine hydrochloride; Namenda
• Storage: Room temperature
• IUPAC Name: 3,5-dimethyladamantan-1-amine;hydrochloride
• InChI: 1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
• InChIKey: LDDHMLJTFXJGPI-VXMZOEJHSA-N
• SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl

Memantine Hydrochloride(CAT: A000392) is an FDA-approved N-methyl-D-aspartate (NMDA) receptor antagonist widely used in neuropharmacological and clinical research. By modulating glutamatergic neurotransmission, it prevents excessive calcium influx and mitigates excitotoxicity, a key mechanism in neurodegenerative diseases. Memantine is best known as a therapeutic agent for moderate-to-severe Alzheimer’s disease, where it improves cognition and daily functioning. Beyond dementia, it is studied in models of Parkinson’s disease, stroke, neuropathic pain, and psychiatric disorders, offering broad neurological relevance. Its favorable safety profile and well-characterized pharmacokinetics make Memantine Hydrochloride a valuable reference compound for CNS drug development and excitotoxicity research.