(melle-4)cyclosporin

• CAT Number: I013994
• CAS Number: 143205-42-9
• Molecular Formula: C62H111N11O12
• Molecular Weight: 1202.611
• Purity: ≥95%
• Storage: Store at RT
• InChI: 1S/C62H111N11O12/c1-25-28-29-40(15)52(75)51-56(79)65-43(27-3)58(81)67(18)33-47(74)71(22)50(39(14)26-2)55(78)66-48(37(10)11)61(84)68(19)44(30-34(4)5)54(77)63-41(16)53(76)64-42(17)57(80)69(20)45(31-35(6)7)59(82)70(21)46(32-36(8)9)60(83)72(23)49(38(12)13)62(85)73(51)24/h25,28,34-46,48-52,75H,26-27,29-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b28-25+/t39-,40+,41-,42+,43-,44-,45-,46-,48-,49-,50-,51-,52+/m0/s1
• InChIKey: RPJPZDVUUKWPGT-FOIHOXPVSA-N
• SMILES: CC[C@H](C)[C@@H]1N(C)C(=O)CN(C)C(=O)[C@H](CC)NC(=O)[C@H]([C@H](O)[C@H](C)CC=CC)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC1=O)C(C)C

(Melle-4)cyclosporin(CAT: I013994) is a potent inhibitor of mitochondrial permeability transition. It belongs to the cyclosporin family of compounds and is modified with a methyl-leucine residue at position 4. This modification enhances its ability to inhibit the opening of the mitochondrial permeability transition pore, a phenomenon involved in cell death processes such as apoptosis and necrosis. By inhibiting mitochondrial permeability transition, (Melle-4)cyclosporin has the potential to protect cells from various forms of injury and contribute to the development of therapeutic strategies for conditions related to mitochondrial dysfunction.