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Melflufen hydrochloride

Melflufen hydrochloride

  • CAT Number: I014770
  • CAS Number: 380449-54-7
  • Molecular Formula: C₂₄H₃₁Cl₃FN₃O₃
  • Molecular Weight: 534.88
  • Purity: 98%
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Melflufen (Melphalan flufenamide) hydrochloride (Cat.No:I014770), a dipeptide prodrug of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells

Catalog Number I014770
CAS Number 380449-54-7
Synonyms

Melflufen hydrochloride; Melphalan flufenamide hydrochloride

Molecular Formula

C₂₄H₃₁Cl₃FN₃O₃

Purity 98
Related CAS 380449-51-4
Analysis method HPLC
Reference

[1]. Chauhan D, et al. In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells. Clin Cancer Res. 2013;19(11):3019-3031.

<br>[2]. Ray A, et al. A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells. Br J Haematol. 2016;174(3):397-409.

<br>[3]. McAndrews KM, et, al. Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer. 2019 Mar 30;18(1):52.

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