Meldonium dihydrate

• CAT Number: A000466
• CAS Number: 86426-17-7
• Molecular Formula: C6H18N2O4
• Molecular Weight: 182.22
• Purity: ≥95%
• Target: GBB hydroxylase
• Storage: 3 years -20C powder
• Related CAS: 76144-81-5
• IUPAC Name: 3-[(trimethylazaniumyl)amino]propanoate;dihydrate
• InChI: InChI=1S/C6H14N2O2.2H2O/c1-8(2,3)7-5-4-6(9)10;;/h7H,4-5H2,1-3H3;2*1H2
• InChIKey: JFWLFLLRLZSBRA-UHFFFAOYSA-N
• SMILES: C[N+](C)(C)NCCC(=O)[O-].O.O

Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.Mildronate (40 μM) inhibits the reaction of γ-butyrobetaine hydroxylase with γ-butyrobetaine with Km and Vmax of 36.8 μM and 0.08 nmol/min/mg protein, respectively.Mildronate administered orally to rats for 10 days (150 mg/kg) elicits a reduction in myocardial free camitine and long-chain acyl carnitine content by 63.7 and 74.3%, respectively. Mildronate treatment (100 mg/kg, orally) subsequent administration of isoproterenol results in a reduction in free camitine concentration by 48.7% in comparison with the rats receiving isoproterenol. A prior administration of Mildronate effectively protects the myocardium from isoproterenol-induced variations in the content of ATP and myocardial energy charge, as well as preventing a rise in creatine phosphokinase and lactic dehydrogenase activity.