Melatonin

• CAT Number: I004727
• CAS Number: 73-31-4
• Molecular Formula: C13H16N2O2
• Molecular Weight: 232.3
• Purity: ≥95%
• Target: Others
• Solubility: DMSO 47 mg/mLWater <1 mg/mLEthanol 47 mg/mL
• Storage: -20°C
• IUPAC Name: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
• InChI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
• InChIKey: DRLFMBDRBRZALE-UHFFFAOYSA-N
• SMILES: CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC

Melatonin (Cat No.: I004727) is an indispensable natural hormone in the human body, which controls and affects the secretion of other different hormones. Melatonin is a hormone produced by the pineal gland. Melatonin is a highly conserved, non-receptor free radical scavenger and broad-spectrum antioxidant. Melatonin helps protect against ischemia-reperfusion injury in the liver, brain, heart muscle, gut, and kidneys.

Reference

1:Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders. Pagan C, Goubran-Botros H, Delorme R, Benabou M, Lemière N, Murray K, Amsellem F, Callebert J, Chaste P, Jamain S, Fauchereau F, Huguet G, Maronde E, Leboyer M, Launay JM, Bourgeron T.Sci Rep. 2017 May 18;7(1):2096. doi: 10.1038/s41598-017-02152-x. PMID: 28522826 2:Regulation of bone mass through pineal-derived melatonin-MT2 pathway. Sharan K, Lewis K, Furukawa T, Yadav VK.J Pineal Res. 2017 May 17. doi: 10.1111/jpi.12423. [Epub ahead of print] PMID: 28512916 3:Melatonin influences the sonic hedgehog signaling pathway in porcine cumulus oocyte complexes. Lee S, Jin JX, Taweechaipaisankul A, Kim GA, Ahn C, Lee BC.J Pineal Res. 2017 May 17. doi: 10.1111/jpi.12424. [Epub ahead of print] PMID: 28512846 4:[Melatonin in a woman/’s life: from birth to menopause]. Usoltseva EN, Bruhina EV, Danilova MV.Adv Gerontol. 2015;28(4):701-707. Russian. PMID: 28509458 5:The melatonin immunomodulatory actions in radiotherapy. Najafi M, Shirazi A, Motevaseli E, Geraily G, Norouzi F, Heidari M, Rezapoor S.Biophys Rev. 2017 Apr;9(2):139-148. doi: 10.1007/s12551-017-0256-8. Epub 2017 Mar 27. Review. PMID: 28510090 Free PMC Article6:Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. Jenwitheesuk A, Boontem P, Wongchitrat P, Tocharus J, Mukda S, Govitrapong P.EXCLI J. 2017 Mar 23;16:340-353. doi: 10.17179/excli2016-852. eCollection 2017. PMID: 28507478 Free PMC Article7:Melatonin protects mice against stress-induced inflammation through enhancement of M2 macrophage polarization. Yi WJ, Kim TS.Int Immunopharmacol. 2017 May 12;48:146-158. doi: 10.1016/j.intimp.2017.05.006. [Epub ahead of print] PMID: 28505494 8:Melatonin Secretion Is Increased in Children with Severe Traumatic Brain Injury. Marseglia L, D/’Angelo G, Manti S, Rulli I, Salvo V, Buonocore G, Reiter RJ, Gitto E.Int J Mol Sci. 2017 May 13;18(5). pii: E1053. doi: 10.3390/ijms18051053. PMID: 28505079 Free Article9:The Effects of Melatonin in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial. Pakravan H, Ahmadian M, Fani A, Aghaee D, Brumanad S, Pakzad B.Adv Biomed Res. 2017 Apr 17;6:40. doi: 10.4103/2277-9175.204593. eCollection 2017. PMID: 28503495 Free PMC Article10:Melatonin: Pharmacology, Functions and Therapeutic Benefits. Tordjman S, Chokron S, Delorme R, Charrier A, Bellissant E, Jaafari N, Fougerou C.Curr Neuropharmacol. 2017 Apr;15(3):434-443. doi: 10.2174/1570159X14666161228122115. Review. PMID: 28503116