• CAT Number: I005710
  • CAS Number: 97207-47-1
  • Molecular Formula: C17H12N2O2
  • Molecular Weight: 276.29
  • Purity: ≥95%
Inquiry Now

Meisoindigo(Cat No.:I005710), also known as Dian III, is a derivative of Indirubin (HY-N0117), which causes acute myeloid leukemia (AML) cell cycle arrest at G0/G1 phase and induces apoptosis. Meisoindigo has high antitumor activity.If you need, please contact us in time, we will reply you as soon as possible within 24 hours.

Catalog Number I005710
CAS Number 97207-47-1
Molecular Formula


Purity 95%
Target Apoptosis Inducers
Solubility DMSO: ≥ 51 mg/mL
Storage Sealed in dry,Room Temperature
IUPAC Name 3-(2-hydroxy-1-methylindol-3-yl)indol-2-one
InChI InChI=1S/C17H12N2O2/c1-19-13-9-5-3-7-11(13)15(17(19)21)14-10-6-2-4-8-12(10)18-16(14)20/h2-9,21H,1H3

</br>1:Meisoindigo, but not its core chemical structure indirubin, inhibits zebrafish interstitial leukocyte chemotactic migration. Ye B, Xiong X, Deng X, Gu L, Wang Q, Zeng Z, Gao X, Gao Q, Wang Y.Pharm Biol. 2017 Dec;55(1):673-679. PMID: 27981893 </br>2:Evaluation of meisoindigo, an indirubin derivative: in vitro antileukemic activity and in vivo pharmacokinetics. Huang M, Lin HS, Lee YS, Ho PC.Int J Oncol. 2014 Oct;45(4):1724-34. doi: 10.3892/ijo.2014.2548. Epub 2014 Jul 21. PMID: 25050545 </br>3:[Mechanism about therapeutic effect of meisoindigo on psoriasis via down-regulation of the TLR4-TAK-NF-kappaB pathways]. Zhang HJ, Zhang Y, Jin J, Zhou WQ, Chen XG.Yao Xue Xue Bao. 2013 Apr;48(4):503-7. Chinese. PMID: 23833936 </br>4:[Immuno-regulatory effect of 3/’-meisoindigo in mice of various germlines]. Wang XJ, Yin SM, Ma LP, Nie DN, Xie SF, Li YQ.Zhong Yao Cai. 2010 Jul;33(7):1124-9. Chinese. PMID: 21137371 </br>5:[Effect of Meisoindigo on Wnt signal pathway in K562 and HL-60 cells]. Zuo MX, Li Y, Zhou JH, Wang HB, Chen XG.Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Jun;18(3):579-82. Chinese. PMID: 20561405 </br>6:Meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. Lee CC, Lin CP, Lee YL, Wang GC, Cheng YC, Liu HE.Leuk Lymphoma. 2010 May;51(5):897-905. doi: 10.3109/10428191003672115. PMID: 20233051 </br>7:Identification of circulatory and excretory metabolites of meisoindigo in rat plasma, urine and feces by high-performance liquid chromatography coupled with positive electrospray ionization tandem mass spectrometry. Huang M, Lee YS, Ho PC.Rapid Commun Mass Spectrom. 2010 Mar;24(6):729-41. doi: 10.1002/rcm.4434. PMID: 20169560 </br>8:Identification of metabolites of meisoindigo in rat, pig and human liver microsomes by UFLC-MS/MS. Huang M, Ho PC.Biochem Pharmacol. 2009 Apr 15;77(8):1418-28. doi: 10.1016/j.bcp.2009.01.012. Epub 2009 Jan 29. PMID: 19426681 </br>9:[Effect on bcr-abl signaling pathway and the mechanisms of apoptosis induction by meisoindigo in K562 cells]. Liu BC, Xiao ZJ.Zhonghua Xue Ye Xue Za Zhi. 2008 Dec;29(12):815-8. Chinese. PMID: 19176035 </br>10:The antitumor activity of meisoindigo against human colorectal cancer HT-29 cells in vitro and in vivo. Mingxin Z, Yan L, Hongbo W, Jianhua Z, Hongyan L, He L, Hongqi X, Sen Z, Xiaoguang C.J Chemother. 2008 Dec;20(6):728-33. PMID: 19129071

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!