Leptomycin B

• CAT Number: I010486
• CAS Number: 87081-35-4
• Molecular Formula: C₃₃H₄₈O₆
• Molecular Weight: 540.73
• Purity: ≥95%
• Solubility: Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 27μg/ml)
• Storage: Store at -20℃
• IUPAC Name: (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-2,3-dihydropyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid
• InChI: InChI=1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,
• InChIKey: YACHGFWEQXFSBS-XYERBDPFSA-N
• SMILES: CCC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C=CC1C(C=CC(=O)O1)C

Leptomycin B (Cat.No:I010486) is a natural compound derived from Streptomyces bacteria. It is a potent inhibitor of nuclear export, specifically targeting the CRM1 protein. By blocking the export of certain proteins from the nucleus, Leptomycin B disrupts critical cellular processes involved in cell proliferation and survival. It has been widely studied for its potential in cancer treatment and as a tool in cell biology research.

Reference

Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. Jang B.C. et al. J. Biol. Chem. 2003, 278, 2773.Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Kudo N. et al. Exp. Cell. Res. 1998, 242, 540.CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Fukuda M. et al. Nature 1997, 390, 308. Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Taagepera S. et al. Proc. Natl. Acad. Sci. USA 1998, 95, 7457.