For research use only. Not for therapeutic Use.
MEISi-2 (Cat No.: I031889) is a small-molecule inhibitor targeting MEIS (myeloid ecotropic viral integration site) homeobox proteins, particularly MEIS1, which are transcription factors involved in hematopoiesis and leukemogenesis. By disrupting MEIS-DNA interactions, MEISi-2 impairs gene expression programs critical for stem cell maintenance and leukemia progression. It has shown promise in preclinical studies for modulating hematopoietic stem cell function and as a potential therapeutic strategy in acute myeloid leukemia (AML). MEISi-2 is valuable for studying MEIS-driven transcriptional regulation and hematologic malignancies.
| CAS Number | 2250156-71-7 |
| Synonyms | 4-hydroxy-N-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]benzamide |
| Molecular Formula | C18H14N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H14N2O3/c21-14-8-5-13(6-9-14)18(23)20-19-11-16-15-4-2-1-3-12(15)7-10-17(16)22/h1-11,21-22H,(H,20,23)/b19-11+ |
| InChIKey | BBWITAIHTBXEMO-YBFXNURJSA-N |
| SMILES | C1=CC=C2C(=C1)C=CC(=C2C=NNC(=O)C3=CC=C(C=C3)O)O |
| Reference | [1]. Raife Dilek Turan, et al. Development of Small Molecule MEIS Inhibitors that modulate HSC activity. Sci Rep. 2020; 10: 7994. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
