Mefuparib hydrochloride

• CAT Number: I016420
• CAS Number: 1449746-00-2
• Molecular Formula: C₁₇H₁₆ClFN₂O₂
• Molecular Weight: 334.77
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 5-fluoro-2-[4-(methylaminomethyl)phenyl]-1-benzofuran-7-carboxamide;hydrochloride
• InChI: InChI=1S/C17H15FN2O2.ClH/c1-20-9-10-2-4-11(5-3-10)15-7-12-6-13(18)8-14(17(19)21)16(12)22-15;/h2-8,20H,9H2,1H3,(H2,19,21);1H
• InChIKey: GPFWTAVHQKERKY-UHFFFAOYSA-N
• SMILES: CNCC1=CC=C(C=C1)C2=CC3=CC(=CC(=C3O2)C(=O)N)F.Cl

Mefuparib hydrochloride (Cat No.:I016420) is a potent and selective inhibitor of PARP1/2, enzymes involved in DNA repair processes. With IC50 values of 3.2 nM and 1.9 nM for PARP1 and PARP2, respectively, MPH competes with the substrate, inhibiting their activity. MPH has demonstrated the ability to induce apoptosis and exhibits significant anticancer activity both in vitro and in vivo. As an orally active compound, MPH holds promise as a potential therapeutic agent for the treatment of cancer.

Reference

[1]. He JX, et al. Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution. Oncotarget. 2017 Jan 17;8(3):4156-4168.[2]. Nie D, et al. Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk-Shell Structure Augment Cancer Chemotherapy. Nano Lett. 2020 Feb 12;20(2):936-946.