ME-1111

• CAT Number: I007938
• CAS Number: 1391758-52-3
• Molecular Formula: C12H14N2O
• Molecular Weight: 202.257
• Purity: ≥95%
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 2-(3,5-dimethylpyrazol-1-yl)-5-methylphenol
• InChI: InChI=1S/C12H14N2O/c1-8-4-5-11(12(15)6-8)14-10(3)7-9(2)13-14/h4-7,15H,1-3H3
• InChIKey: VQXHPRBERPTLQW-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C=C1)N2C(=CC(=N2)C)C)O

ME-1111 is a Antifungal Agent for Topical Treatment of Onychomycosis. ME1111 showed potent antifungal activity against Trichophyton rubrum and Trichophyton mentagrophytes (the major etiologic agents of onychomycosis) strains isolated in Japan and reference fungal strains with an MIC range of 0.12 to 0.5 mg/liter and an MIC50 and MIC90 of 0.5 mg/liter for both. ME1111 is a promising topical medication for the treatment of onychomycosis and therefore warrants further clinical evaluation.

Reference

1:Hui X, Jung EC, Zhu H, Maibach HI. Antifungal ME1111 in vitro human onychopharmacokinetics. Drug Dev Ind Pharm. 2016 Jul 4:1-8. [Epub ahead of print] PubMed PMID: 27309768. 2:Long L, Hager C, Ghannoum M. Evaluation of the Efficacy of ME1111 in the Topical Treatment of Dermatophytosis in a Guinea Pig Model. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2343-5. doi: 10.1128/AAC.03073-15. Print 2016 Apr. PubMed PMID: 26833160; PubMed Central PMCID: PMC4808162.