MD-222

• CAT Number: I031695
• CAS Number: 2136246-72-3
• Molecular Formula: C48H47Cl2FN6O6
• Molecular Weight: 893.8384
• Purity: 98%
• Solubility: To be determined
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentyl)carbamoyl)phenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide
• InChI: InChI=1S/C48H47Cl2FN6O6/c49-29-16-19-34-36(25-29)54-46(63)48(34)39(32-12-8-13-35(50)40(32)51)41(56-47(48)22-4-2-5-23-47)44(61)53-30-17-14-28(15-18-30)42(59)52-24-6-1-3-9-27-10-7-11-31-33(27)26-57(45(31)62)37-20-21-38(58)55-43(37)60/h7-8,10-19,25,37,39,41,56H,1-6,9,20-24,26H2,(H,52,59)(H,53,61)(H,54,63)(H,55,58,60)/t37?,39-,41+,48+/m0/s1
• InChIKey: RRSNDVCODIMOFX-MPKOGUQCSA-N
• SMILES: O=C([C@H](N1)[C@H](C2=CC=CC(Cl)=C2F)[C@]3(C(NC4=C3C=CC(Cl)=C4)=O)C51CCCCC5)NC6=CC=C(C(NCCCCCC7=CC=CC8=C7CN(C(CC9)C(NC9=O)=O)C8=O)=O)C=C6

MD-222 (Cat.No:I031695) is a novel small molecule inhibitor that targets the interaction between MDM2 and p53, two key proteins involved in regulating cell cycle and apoptosis. By blocking this interaction, MD-222 disrupts the negative feedback loop and promotes p53-mediated tumor suppression. It shows promise as a potential therapeutic agent for p53-mutant cancers.

Reference

1: Yang J, Li Y, Aguilar A, Liu Z, Yang CY, Wang S. Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders. J Med Chem. 2019 Nov 14;62(21):9471-9487. doi: 10.1021/acs.jmedchem.9b00846. Epub 2019 Oct 21. PMID: 31560543; PMCID: PMC7354697.