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Mcl1-IN-1

Mcl1-IN-1

  • CAT Number: I004664
  • CAS Number: 713492-66-1
  • Molecular Formula: C23H18ClN3O4
  • Molecular Weight: 435.86
  • Purity: ≥95%
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<p style=/line-height:25px/>Mcl1-IN-1 (Cat.No:I004664) is a potent Mcl-1-selective inhibitor relative to the related Bcl-2 family protein Bcl-xL; demonstrated good Mcl-1 inhibition (IC50 = 2.4 uM) with no appreciable inhibition of Bcl-xL at 100 uM.

Catalog Number I004664
CAS Number 713492-66-1
Synonyms

2-(2-((5-chloro-8-hydroxyquinolin-7-yl)(pyridin-2-ylamino)methyl)phenoxy)acetic acid

Molecular Formula

C23H18ClN3O4

Purity 95%
Target Bcl-2 Family
Solubility DMSO: ≥ 50 mg/mL
Storage Store at -20°C
IC50 2.4 uM
Reference

<p style=/line-height:25px/>
<br>[1]. Richard DJ, et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1;21(21):6642-9.
</p>

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