Mcl-1 inhibitor 6

• CAT Number: I045381
• CAS Number: 2598978-56-2
• Molecular Formula: C26H28ClNO6S
• Molecular Weight: 518.02
• Purity: ≥95%
• Synonyms: 4-(4-acetylphenyl)sulfonyl-1-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-3,5-dimethylpyrrole-2-carboxylic acid
• InChI: InChI=1S/C26H28ClNO6S/c1-15-13-21(14-16(2)23(15)27)34-12-6-11-28-18(4)25(17(3)24(28)26(30)31)35(32,33)22-9-7-20(8-10-22)19(5)29/h7-10,13-14H,6,11-12H2,1-5H3,(H,30,31)
• InChIKey: MKUKBCVJQXCFKM-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC(=C1Cl)C)OCCCN2C(=C(C(=C2C(=O)O)C)S(=O)(=O)C3=CC=C(C=C3)C(=O)C)C

MCL-1 Inhibitor 6 (Cat No.: I045381) is a small-molecule compound designed to selectively inhibit myeloid cell leukemia 1 (MCL-1), an anti-apoptotic protein in the BCL-2 family that promotes cancer cell survival. Overexpression of MCL-1 is common in various cancers, contributing to resistance to chemotherapy and other targeted therapies. By binding to MCL-1’s BH3-binding groove, Inhibitor 6 restores apoptotic signaling in tumor cells. It is primarily used in preclinical studies to investigate MCL-1’s role in oncogenesis and to evaluate potential combination cancer therapies.

Reference

[1]. Peng-Ju Zhu, et al. Discovery of 3,5-Dimethyl-4-Sulfonyl-1 H-Pyrrole-Based Myeloid Cell Leukemia 1 Inhibitors with High Affinity, Selectivity, and Oral Bioavailability. J Med Chem. 2021 Aug 12;64(15):11330-11353.
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