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MCC950 sodium

MCC950 sodium

  • CAT Number: I006217
  • CAS Number: 256373-96-3
  • Molecular Formula: C₂₀H₂₃N₂NaO₅S
  • Molecular Weight: 426.46
  • Purity: ≥95%
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MCC950 sodium(CAT: I006217), also known as CP-456773 sodium, is a small molecule inhibitor of the NLRP3 inflammasome, which is a complex involved in the activation of inflammatory responses in the body. MCC950 sodium has been shown to have therapeutic potential in the treatment of various inflammatory diseases, including rheumatoid arthritis, gout, and Alzheimer’s disease. It works by blocking the activity of NLRP3 inflammasome, thereby reducing the production of inflammatory cytokines. MCC950 sodium has been studied in several preclinical and clinical trials and has shown promising results in reducing inflammation and improving symptoms in animal models of various inflammatory diseases. It is important to note that MCC950 sodium is intended for research purposes only and should not be used for any other purposes.

Catalog Number I006217
CAS Number 256373-96-3
Molecular Formula

C₂₀H₂₃N₂NaO₅S

Purity 95%
Target NLRP3 inhibitor
Solubility Soluble in DMSO, not in water
Storage 0 - 4°C for short term ,or -20 °C for long term
Related CAS 210826-40-7
IC50 7.5 nM
InChI InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1
InChIKey LFQQNXFKPNZRFT-UHFFFAOYSA-M
SMILES CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+]
Reference

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1:Management of untreatable ventricular arrhythmias during pharmacologic challenges with sodium channel blockers for suspected Brugada syndrome. Poli S, Toniolo M, Maiani M, Zanuttini D, Rebellato L, Vendramin I, Dametto E, Bernardi G, Bassi F, Napolitano C, Livi U, Proclemer A.Europace. 2017 May 17. doi: 10.1093/europace/eux092. [Epub ahead of print] PMID: 28521022 <br />
2:Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy. Holland KD, Bouley TM, Horn PS.Epilepsia. 2017 May 18. doi: 10.1111/epi.13798. [Epub ahead of print] PMID: 28518218 <br />
3:Ag-Catalyzed Oxidative Cyclization Reaction of 1,6-Enynes and Sodium Sulfinate: Access to Sulfonylated Benzofurans. Wu W, Yi S, Huang W, Luo D, Jiang H.Org Lett. 2017 May 18. doi: 10.1021/acs.orglett.7b00980. [Epub ahead of print] PMID: 28517933 <br />
4:Sodium-Glucose Co-transporter-2 Inhibitors and Diabetic Ketoacidosis. An Updated Review of the Literature. Bonora BM, Avogaro A, Fadini GP.Diabetes Obes Metab. 2017 May 18. doi: 10.1111/dom.13012. [Epub ahead of print] Review. PMID: 28517913 <br />
5:Effects of calcineurin inhibitors on sodium excretion in recipients of allogeneic hematopoietic stem cell transplantation. Saburi M, Kohashi S, Kato J, Koda Y, Sakurai M, Toyama T, Kikuchi T, Karigane D, Yuda S, Yamane Y, Hashida R, Abe R, Nakazato T, Hirahashi J, Ogata M, Okamoto S, Mori T.Int J Hematol. 2017 May 17. doi: 10.1007/s12185-017-2253-x. [Epub ahead of print] PMID: 28516402 <br />
6:Intracellular morphological changes in Staphylococcus aureus induced by treatment with sodium hypochlorite. Ujimine S, Tone S, Saito M, Yamada S.Med Mol Morphol. 2017 May 17. doi: 10.1007/s00795-017-0159-6. [Epub ahead of print] PMID: 28516285 <br />
7:GPNA inhibits the sodium-independent transport system L for neutral amino acids. Chiu M, Sabino C, Taurino G, Bianchi MG, Andreoli R, Giuliani N, Bussolati O.Amino Acids. 2017 May 17. doi: 10.1007/s00726-017-2436-z. [Epub ahead of print] PMID: 28516268 <br />
8:Effects of phosalone consumption via feeding with or without sodium bentonite on performance, blood metabolites and its transition to milk of Iranian Baluchi sheep. Kazemi M, Torbaghan AE, Tahmasbi AM, Valizadeh R, Naserian AA.J Anim Sci Technol. 2017 May 15;59:10. doi: 10.1186/s40781-017-0135-7. eCollection 2017. PMID: 28515956 Free Article<br />
9:Functional Assessment of Sodium Chloride Co-transporter NCC Mutants in Polarized Mammalian Epithelial Cells. Rosenbaek LL, Rizzo F, MacAulay N, Staub O, Fenton RA.Am J Physiol Renal Physiol. 2017 May 17:ajprenal.00088.2017. doi: 10.1152/ajprenal.00088.2017. [Epub ahead of print] PMID: 28515174 <br />
10:Comparative Antimicrobial Efficacy of <i>Eucalyptus Galbie</i> and <i>Myrtus Communis L.</i> Extracts, Chlorhexidine and Sodium Hypochlorite against <i>Enterococcus Faecalis</i>. Nourzadeh M, Amini A, Fakoor F, Raoof M, Sharififar F.Iran Endod J. 2017 Spring;12(2):205-210. doi: 10.22037/iej.2017.40. PMID: 28512487 Free PMC Article

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