MC-Val-Cit-PAB-clindamycin

• CAT Number: I018047
• CAS Number: 1639793-13-7
• Molecular Formula: C46H72Cl2N8O11S
• Molecular Weight: 1016.08
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl]-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidin-1-ium-2-carboxamide
• InChI: InChI=1S/C46H71ClN8O11S/c1-7-12-29-23-32(43(63)53-37(27(4)47)41-39(60)38(59)40(61)45(66-41)67-6)55(5,25-29)24-28-15-17-30(18-16-28)50-42(62)31(13-11-21-49-46(48)65)51-44(64)36(26(2)3)52-33(56)14-9-8-10-22-54-34(57)19-20-35(54)58/h15-20,26-27,29,31-32,36-41,45,59-61H,7-14,21-25H2,1-6H3,(H6-,48,49,50,51,52,53,56,62,63,64,65)/p+1/t27-,29+,31-,32-,36-,37+,38-,39+,40+,41+,45+,55?/m0/s1
• InChIKey: KINAEBJVJLCQDX-DCAHZPCSSA-O
• SMILES: CCC[C@@H]1C[C@H]([N+](C1)(C)CC2=CC=C(C=C2)NC(=O)[C@H](CCCNC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)CCCCCN3C(=O)C=CC3=O)C(=O)N[C@@H]([C@@H]4[C@@H]([C@@H]([C@H]([C@H](O4)SC)O)O)O)[C@H](C)Cl

MC-Val-Cit-PAB-clindamycin（Cat No.:I018047）is an antibody–drug conjugate (ADC) linker–payload construct designed for targeted therapeutic delivery. It features a maleimidocaproyl (MC) linker for stable antibody conjugation, a valine-citrulline (Val-Cit) dipeptide for protease-sensitive cleavage, and a para-aminobenzyloxycarbonyl (PAB) self-immolative spacer enabling controlled intracellular release. Clindamycin, an antibiotic payload, is liberated upon lysosomal degradation, allowing selective action at the disease site while minimizing systemic exposure. This construct is explored in research as a platform for targeted antimicrobial and anticancer strategies, combining precise drug delivery with improved efficacy and reduced toxicity.