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MC-SN38

MC-SN38

  • CAT Number: I015243
  • CAS Number: 1473403-87-0
  • Molecular Formula: C₃₂H₃₁N₃O₈
  • Molecular Weight: 585.6
  • Purity: ≥95%
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MC-SN38 (Cat.No:I015243) is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks.

Catalog Number I015243
CAS Number 1473403-87-0
Molecular Formula

C₃₂H₃₁N₃O₈

Purity 95%
Reference

[1]. Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56.<br>[2]. Kawato Y, et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991;51(16):4187-4191.

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