MBQ-167

• CAT Number: I019753
• CAS Number: 2097938-73-1
• Molecular Formula: C₂₂H₁₈N₄
• Molecular Weight: 338.41
• Purity: ≥95%
• Storage: 2-8°C
• IUPAC Name: 9-ethyl-3-(5-phenyltriazol-1-yl)carbazole
• InChI: InChI=1S/C22H18N4/c1-2-25-20-11-7-6-10-18(20)19-14-17(12-13-21(19)25)26-22(15-23-24-26)16-8-4-3-5-9-16/h3-15H,2H2,1H3
• InChIKey: LJCANTASZGYJLG-UHFFFAOYSA-N
• SMILES: CCN1C2=C(C=C(C=C2)N3C(=CN=N3)C4=CC=CC=C4)C5=CC=CC=C51

MBQ-167（Cat No.:I019753） is a dual inhibitor that targets both Rac and Cdc42, two small GTPases involved in cellular signaling pathways. In MDA-MB-231 cells, MBQ-167 demonstrates inhibitory activity against Rac 1/2/3 with an IC50 of 103 nM and against Cdc42 with an IC50 of 78 nM. By selectively blocking the activity of these GTPases, MBQ-167 may disrupt their downstream signaling pathways and potentially impact cellular processes such as cytoskeletal rearrangement, cell migration, and proliferation.

Reference

[1]. Humphries-Bickley T, et al. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. Mol Cancer Ther. 2017 May;16(5):805-818.