Maytansinol

• CAT Number: I004129
• CAS Number: 57103-68-1
• Molecular Formula: C28H37ClN2O8
• Molecular Weight: 565.06
• Purity: ≥95%
• Target: Microtubule/Tubulin
• Solubility: DMSO: ≥ 35 mg/mL
• Storage: Store at -20C
• IUPAC Name: (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaene-8,23-dione
• InChI: InChI=1S/C28H37ClN2O8/c1-15-8-7-9-22(37-6)28(35)14-20(38-26(34)30-28)16(2)25-27(3,39-25)21(32)13-23(33)31(4)18-11-17(10-15)12-19(36-5)24(18)29/h7-9,11-12,16,20-22,25,32,35H,10,13-14H2,1-6H3,(H,30,34)/b9-7+,15-8+/t16-,20+,21+,22-,25+,27+,28+/m1/s1
• InChIKey: QWPXBEHQFHACTK-RZKXNLMUSA-N
• SMILES: CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)O)C)C)OC)(NC(=O)O2)O

Maytansinol (CAT: I004129) is a naturally occurring compound derived from the Maytenus species of plants. It belongs to the class of maytansinoids known for their potent cytotoxicity and antitumor activity. Maytansinol acts by inhibiting microtubule assembly and disrupting mitotic spindle formation, leading to cell cycle arrest and apoptosis in cancer cells. Due to its cytotoxic effects, maytansinol has been investigated as a potential anticancer agent and has shown promising results in preclinical studies. However, its clinical development has been limited due to its poor solubility and toxicity. Maytansinol is an important compound for developing novel cytotoxic agents and targeted drug delivery systems in cancer therapy.

Reference

1. Edwards A, et al. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul;4(4):496-503.