Mavacamten

• CAT Number: I007910
• CAS Number: 1642288-47-8
• Molecular Formula: C15H19N3O2
• Molecular Weight: 273.33
• Purity: ≥95%
• Target: Myosin Inhibitor
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 6-[[(1S)-1-phenylethyl]amino]-3-propan-2-yl-1H-pyrimidine-2,4-dione
• InChI: InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1
• InChIKey: RLCLASQCAPXVLM-NSHDSACASA-N
• SMILES: CC(C)N1C(=O)C=C(NC1=O)NC(C)C2=CC=CC=C2

Mavacamten（Cat No.:I007910）, also known as SAR-439152 and MYK-461, is a myosin inhibitor potentially for the treatment of hypertrophic cardiomyopathy. SAR-439152 reduces contractility by decreasing the adenosine triphosphatase activity of the cardiac myosin heavy chain.

Reference

1: Green EM, Wakimoto H, Anderson RL, Evanchik MJ, Gorham JM, Harrison BC, Henze M, Kawas R, Oslob JD, Rodriguez HM, Song Y, Wan W, Leinwand LA, Spudich JA, McDowell RS, Seidman JG, Seidman CE. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351(6273):617-21. doi: 10.1126/science.aad3456. PubMed PMID: 26912705; PubMed Central PMCID: PMC4784435.