Matrine

• CAT Number: I003881
• CAS Number: 519-02-8
• Molecular Formula: C15H24N2O
• Molecular Weight: 248.4
• Purity: ≥95%
• Target: Apoptosis Inducers
• Solubility: DMSO：49 mg/mL，H2O：11 mg/mL （warmed)
• Storage: 3 years -20C powder
• IC50: 540 μg/ml (inhibit gastric cancer cell line MNK45, MTT) [1]
• InChIKey: ZSBXGIUJOOQZMP-JLNYLFASSA-N

Matrine (CAT: I003881) is a natural alkaloid compound derived from the root of the traditional Chinese herb Sophora flavescens. It has been used in traditional medicine for centuries due to its various pharmacological properties. Matrine exhibits anti-inflammatory, anticancer, antiviral, and immunomodulatory activities. It has been shown to inhibit the growth of cancer cells by inducing cell cycle arrest and apoptosis. Matrine also possesses anti-inflammatory effects by suppressing the production of pro-inflammatory cytokines and inhibiting the activation of inflammatory signaling pathways. Furthermore, it has demonstrated antiviral activity against several viruses, including hepatitis B and C viruses.

Reference

[1]. Luo C, et al. Inhibition of matrine against gastric cancer cell line MNK45 growth and its anti-tumor mechanism. Mol Biol Rep. 2012 May;39(5):5459-64.
[2]. Tan C, et al. Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells. Oncol Rep. 2013 Nov;30(5):2529-35.
[3]. Li X, et al. Regulation of endothelial nitric oxide synthase and asymmetric dimethylarginine by matrine attenuates isoproterenol-induced acute myocardial injury in rats. J Pharm Pharmacol. 2012 Aug;64(8):1107-18.
[4]. Zhang B, et al. Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice. Eur J Pharm Sci. 2011 Dec 18;44(5):573-9.