Maropitant

• CAT Number: I001792
• CAS Number: 147116-67-4
• Molecular Formula: C32H40N2O
• Molecular Weight: 468.67
• Purity: ≥95%
• Target: Substance P/NK1 Receptor
• Solubility: DMSO < 8 mg/ml
• Storage: Store at -20°C
• IUPAC Name: (2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine
• InChI: InChI=1S/C32H40N2O/c1-32(2,3)27-15-16-28(35-4)26(21-27)22-33-30-25-17-19-34(20-18-25)31(30)29(23-11-7-5-8-12-23)24-13-9-6-10-14-24/h5-16,21,25,29-31,33H,17-20,22H2,1-4H3/t30-,31-/m0/s1
• InChIKey: OMPCVMLFFSQFIX-CONSDPRKSA-N
• SMILES: CC(C)(C)C1=CC(=C(C=C1)OC)CNC2C3CCN(C2C(C4=CC=CC=C4)C5=CC=CC=C5)CC3

Maropitant (Cat.No:I001792) is a selective neurokinin-1 (NK1) receptor antagonist primarily used in veterinary medicine to prevent and treat vomiting in dogs. It works by blocking the binding of substance P, a neurotransmitter involved in the emetic (vomiting) response. Maropitant is available as an oral tablet or injectable formulation for veterinary use.

Reference

1:Comparative efficacy of metoclopramide, ondansetron and maropitant in preventing parvoviral enteritis-induced emesis in dogs. Yalcin E, Keser GO.J Vet Pharmacol Ther. 2017 Feb 14. doi: 10.1111/jvp.12396. [Epub ahead of print] PMID: 28198032 2:Interaction between maropitant and carprofen on sparing of the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs. Fukui S, Ooyama N, Tamura J, Umar MA, Ishizuka T, Itami T, Miyoshi K, Sano T, Yamashita K.J Vet Med Sci. 2017 Mar 18;79(3):502-508. doi: 10.1292/jvms.15-0666. Epub 2017 Jan 21. PMID: 28111373 Free PMC Article3:A comparison between maropitant and metoclopramide for the prevention of morphine-induced nausea and vomiting in dogs. Lorenzutti AM, Martín-Flores M, Litterio NJ, Himelfarb MA, Invaldi SH, Zarazaga MP.Can Vet J. 2017 Jan;58(1):35-38. PMID: 28042152 4:Maropitant administered orally 2-2.5 h prior to morphine and dexmedetomidine reduces the incidence of emesis in cats. Martin-Flores M, Mastrocco A, Lorenzutti AM, Campoy L, Kirch P, Stone M, Learn MM, Boesch JM.J Feline Med Surg. 2016 Aug 18. pii: 1098612X16663595. [Epub ahead of print] PMID: 27538868 5:Effects of maropitant in cats receiving dexmedetomidine and morphine. Martin-Flores M, Sakai DM, Learn MM, Mastrocco A, Campoy L, Boesch JM, Gleed RD.J Am Vet Med Assoc. 2016 Jun 1;248(11):1257-61. doi: 10.2460/javma.248.11.1257. PMID: 27172341 6:Effects of the neurokinin-1 antagonist maropitant on canine gastric emptying assessed by radioscintigraphy and breath test. Schmitz S, Fink T, Failing K, Borsch C, Kunz C, Clemence R, Savary-Bataille K, Neiger R.Tierarztl Prax Ausg K Kleintiere Heimtiere. 2016 Jun 16;44(3):163-9. doi: 10.15654/TPK-150039. Epub 2016 Apr 19. PMID: 27090486 7:Evaluation of oral maropitant as an antiemetic in cats receiving morphine and dexmedetomidine. Martin-Flores M, Sakai DM, Mastrocco A, Learn MM, Campoy L, Kirch PJ, Boesch JM, Gleed RD.J Feline Med Surg. 2015 Nov 3. pii: 1098612X15613389. [Epub ahead of print] PMID: 26534944 8:Comparison of NK-1 Receptor Antagonist (Maropitant) to Morphine as a Pre-Anaesthetic Agent for Canine Ovariohysterectomy. Marquez M, Boscan P, Weir H, Vogel P, Twedt DC.PLoS One. 2015 Oct 29;10(10):e0140734. doi: 10.1371/journal.pone.0140734. eCollection 2015. PMID: 26513745 Free PMC Article9:Evaluation of the antiemetic efficacy of maropitant in dogs medicated with morphine and acepromazine. Lorenzutti AM, Martín-Flores M, Litterio NJ, Himelfarb MA, Zarazaga MP.Vet Anaesth Analg. 2016 Mar;43(2):195-8. doi: 10.1111/vaa.12286. Epub 2015 Jun 19. PMID: 26095960 10:Anti-emetic drug maropitant induces intestinal motility disorder but not anti-inflammatory action in mice. Mikawa S, Yamamoto S, Islam MS, Kaji N, Murata T, Mizuno R, Ozaki H, Hori M.J Vet Med Sci. 2015 Oct;77(10):1195-9. doi: 10.1292/jvms.15-0182. Epub 2015 May 3. PMID: 25947563 Free PMC Article