Mangiferin

• CAT Number: I003665
• CAS Number: 4773-96-0
• Molecular Formula: C19H18O11
• Molecular Weight: 422.34
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C

Mangiferin isolated from Anemarrhena asphodeloides Bunge rhizome, is used for antidiabetes.IC50 value:Target:In vitro: Mangiferin is an O(2)(-) scavenger and that it inhibits expression of the iNOS and TNF-alpha genes, suggesting that it may be of potential value in the treatment of inflammatory and/or neurodegenerative disorders. In addition, mangiferin enhancing TGF-beta gene expression suggests that this polyphenol might also be of value in the prevention of cancer, autoimmune disorders, atherosclerosis and coronary heart disease [3].In vivo: Mangiferin was tested for antidiabetic activity in KK-Ay mice, an animal model of type-2 diabetes. Mangiferin lowered the blood glucose level of KK-Ay mice 3 weeks after oral administration (p < 0.01). However, no effect on the blood glucose level in normal mice was seen, indicating that mangiferin could be useful in treating type-2 diabetes. In addition, mangiferin improved hyperinsulinemia and, on insulin tolerance test, reduced blood glucose levels of KK-Ay mice [1]. The effect of mangiferin (10 and 20 mg/kg, i.p., 28 days) was investigated in STZ-induced diabetic male rats. Insulin-treated rats (6 U/kg, i.p., 28 days) served as positive control. Intraperitoneal administration of mangiferin exhibited significant decrease in glycosylated haemoglobin and CPK levels along with the amelioration of oxidative stress that was comparable to insulin treatment [2].

Reference

[1]. Miura T, et al. Antidiabetic activity of a xanthone compound, mangiferin. Phytomedicine. 2001 Mar;8 (2):85-7.

[2]. S Muruganandan, et al. Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats. Toxicology
Volume 176, Issue 3, 15 July 2002, Pages 165–173

[3]. Leiro JM, et al. In vitro effects of mangiferin on superoxide concentrations and expression of the inducible nitric oxide synthase, tumour necrosis factor-alpha and transforming growth factor-beta genes. Biochem Pharmacol. 2003 Apr 15;65(8):1361-71.