Magnolol

• CAT Number: I003932
• CAS Number: 528-43-8
• Molecular Formula: C18H18O2
• Molecular Weight: 266.33
• Purity: ≥95%
• Solubility: DMSO: 37 mg/mL
• Storage: 2-8°C
• IUPAC Name: 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol
• InChI: InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2
• InChIKey: VVOAZFWZEDHOOU-UHFFFAOYSA-N
• SMILES: C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O

Magnolol（Cat No.:I003932）, the principal polyphenol found in the bark of Magnolia officinalis, exhibits a diverse range of pharmacological activities. It has been recognized for its potential therapeutic effects, including anti-inflammatory, antioxidant, antimicrobial, anticancer, neuroprotective, and cardioprotective properties. Magnolol has been extensively studied for its potential in treating various diseases and conditions, making it a subject of interest in pharmacological research.

Reference

1:Chemoenzymatic Synthesis and α-Glucosidase Inhibitory Activity of Dimeric Neolignans Inspired by Magnolol. Pulvirenti L, Muccilli V, Cardullo N, Spatafora C, Tringali C.J Nat Prod. 2017 May 12. doi: 10.1021/acs.jnatprod.7b00250. [Epub ahead of print] PMID: 28497968 2:Effect of magnolol on cerebral injury and blood brain barrier dysfunction induced by ischemia-reperfusion in vivo and in vitro. Liu X, Chen X, Zhu Y, Wang K, Wang Y.Metab Brain Dis. 2017 Apr 4. doi: 10.1007/s11011-017-0004-6. [Epub ahead of print] PMID: 28378105 3:Quantitative analysis of the therapeutic effect of magnolol on MPTP-induced mouse model of Parkinson/’s disease using in vivo 18F-9-fluoropropyl-(+)-dihydrotetrabenazine PET imaging. Weng CC, Chen ZA, Chao KT, Ee TW, Lin KJ, Chan MH, Hsiao IT, Yen TC, Kung MP, Hsu CH, Wey SP.PLoS One. 2017 Mar 3;12(3):e0173503. doi: 10.1371/journal.pone.0173503. eCollection 2017. PMID: 28257461 Free PMC Article4:Magnolol and honokiol from Magnolia officinalis enhanced antiviral immune responses against grass carp reovirus in Ctenopharyngodon idella kidney cells. Chen X, Hu Y, Shan L, Yu X, Hao K, Wang GX.Fish Shellfish Immunol. 2017 Apr;63:245-254. doi: 10.1016/j.fsi.2017.02.020. Epub 2017 Feb 20. PMID: 28232195 5:Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4+ T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling. Zhang H, Ju B, Zhang X, Zhu Y, Nie Y, Xu Y, Lei Q.Basic Clin Pharmacol Toxicol. 2017 Jun;120(6):560-570. doi: 10.1111/bcpt.12749. Epub 2017 Mar 7. PMID: 28032440 6:Magnolol Enhances Hippocampal Neurogenesis and Exerts Antidepressant-Like Effects in Olfactory Bulbectomized Mice. Matsui N, Akae H, Hirashima N, Kido Y, Tanabe S, Koseki M, Fukuyama Y, Akagi M.Phytother Res. 2016 Nov;30(11):1856-1861. doi: 10.1002/ptr.5695. Epub 2016 Aug 11. PMID: 27510271 7:Protective effect of magnolol-loaded polyketal microparticles on lipopolysaccharide-induced acute lung injury in rats. Tsai T, Kao CY, Chou CL, Liu LC, Chou TC.J Microencapsul. 2016 Aug;33(5):401-11. doi: 10.1080/02652048.2016.1202344. Epub 2016 Jun 29. PMID: 27357644 8:Magnolol pretreatment attenuates heat stress-induced IEC-6 cell injury. Mei C, He SS, Yin P, Xu L, Shi YR, Yu XH, Lyu A, Liu FH, Jiang LS.J Zhejiang Univ Sci B. 2016 Jun;17(6):413-24. doi: 10.1631/jzus.B1500261. PMID: 27256675 Free PMC Article9:Methylation and Esterification of Magnolol for Ameliorating Cutaneous Targeting and Therapeutic Index by Topical Application. Lin CF, Hung CF, Aljuffali IA, Huang YL, Liao WC, Fang JY.Pharm Res. 2016 Sep;33(9):2152-67. doi: 10.1007/s11095-016-1953-x. Epub 2016 May 27. PMID: 27233503 10:[Effect of Magnolol on Proliferation and Apoptosis of HL-60 Cells and Its Molecular Mechanism]. Fang K, Yuan XF, Liao Q, Zhang ZY, Song GH, Guo Q, Ren X, Jiang GS.Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Apr;24(2):388-93. doi: 10.7534/j.issn.1009-2137.2016.02.015. Chinese. PMID: 27150997