Madecassoside

• CAT Number: I003259
• CAS Number: 34540-22-2
• Molecular Formula: C48H78O20
• Molecular Weight: 975.1
• Purity: ≥95%
• Solubility: DMSO ≥ 9.8 mg/mL
• Storage: -20°C
• InChIKey: BNMGUJRJUUDLHW-UHFFFAOYSA-N

Madecassoside (CAT: I003259) is a natural compound derived from Centella Asiatica, a medicinal herb known for its healing properties. It belongs to the triterpenoid saponin family and exhibits various pharmacological activities. Madecassoside has been studied for its wound healing, anti-inflammatory, and antioxidant effects. It promotes collagen synthesis and enhances the migration of fibroblasts, which are crucial for tissue regeneration and wound closure. Madecassoside also inhibits the production of pro-inflammatory cytokines and enzymes, reducing inflammation and promoting tissue repair. Additionally, it displays antioxidant activity, protecting cells from oxidative stress. Madecassoside shows promise in the treatment of skin disorders, including wounds, burns, and dermatitis, and is being explored for its potential in cosmetic and pharmaceutical applications.

Reference

[1]. Zexin Li et al. Madecassoside suppresses proliferation and invasiveness of HGF-induced human hepatocellular carcinoma cells via PKC-cMET-ERK1/2-COX-2-PGE2 pathway. Int Immunopharmacol. 2016 Apr;33:24-32.
[2]. Xia Y et al. Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR-γ in colon. Br J Pharmacol. 2016 Apr;173(7):1219-35
[3]. Su Z et al. Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro. Sci Rep. 2015 Dec 14