For research use only. Not for therapeutic Use.
M8891(CAT: I017367) is an orally active, reversible, and brain-penetrant methionine aminopeptidase-2 (MetAP-2) inhibitor with high selectivity (IC50 = 54 nM; Ki = 4.33 nM) and no activity against MetAP-1 (IC50 >10 µM). It potently inhibits endothelial cell proliferation (IC50 = 20 nM in HUVECs) and tumor cell growth, demonstrating strong antiangiogenic and antitumoral activity. In vivo, daily oral administration (20 mg/kg) produces marked tumor growth suppression. Pharmacokinetic studies reveal low clearance, moderate distribution, and good oral bioavailability (40–80%). With its dual antiangiogenic and anticancer potential, M8891 is a valuable tool for oncology and vascular biology research.
| CAS Number | 1464842-09-8 |
| Synonyms | (3S)-N-[(3,5-difluorophenyl)methyl]-3-hydroxy-1-(1H-indol-5-yl)-2-oxopyrrolidine-3-carboxamide |
| Molecular Formula | C20H17F2N3O3 |
| Purity | ≥95% |
| IUPAC Name | (3S)-N-[(3,5-difluorophenyl)methyl]-3-hydroxy-1-(1H-indol-5-yl)-2-oxopyrrolidine-3-carboxamide |
| InChI | InChI=1S/C20H17F2N3O3/c21-14-7-12(8-15(22)10-14)11-24-18(26)20(28)4-6-25(19(20)27)16-1-2-17-13(9-16)3-5-23-17/h1-3,5,7-10,23,28H,4,6,11H2,(H,24,26)/t20-/m0/s1 |
| InChIKey | WVGGJQVCOTYFPV-FQEVSTJZSA-N |
| SMILES | C1CN(C(=O)C1(C(=O)NCC2=CC(=CC(=C2)F)F)O)C3=CC4=C(C=C3)NC=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
