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m-PEG8-NHS ester

m-PEG8-NHS ester

  • CAT Number: I016727
  • CAS Number: 756525-90-3
  • Molecular Formula: C₂₂H₃₉NO₁₂
  • Molecular Weight: 509.54
  • Purity: ≥95%
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m-PEG8-NHS ester(CAT: I016727) is a non-cleavable eight-unit polyethylene glycol (PEG) linker functionalized with an N-hydroxysuccinimide (NHS) ester group. This linker is widely used in the synthesis of antibody-drug conjugates (ADCs), a class of therapeutic agents that combines the targeting specificity of monoclonal antibodies with the cytotoxic potency of small-molecule drugs. In ADCs, the m-PEG8-NHS ester is attached to the antibody, and the NHS group facilitates the conjugation of the cytotoxic drug to the linker, which is ultimately connected to the antibody.

Catalog Number I016727
CAS Number 756525-90-3
Molecular Formula

C₂₂H₃₉NO₁₂

Purity 95%
Reference

[1]. By Boehnke, et al. Preparation of antibody drug conjugates with NAMPT inhibitors for use in treatment of cancer. Patent WO2019149637A1.

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