m-PEG1-acid (CAT: I032729) is a polyethylene glycol (PEG) derivative that features a terminal carboxylic acid group. This PEG derivative offers versatility in bioconjugation and drug delivery applications. The terminal carboxylic acid group can react with primary amine groups in the presence of activators like EDC (N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide) or DCC (N,N’-Dicyclohexylcarbodiimide) to form stable amide bonds. The hydrophilic PEG spacer enhances solubility in aqueous media, making m-PEG1-acid suitable for use in aqueous-based formulations.
| Catalog Number | I032729 |
| CAS Number | 2544-06-1 |
| Synonyms | m-PEG1-acid |
| Molecular Formula | C4H8O3 |
| Purity | 95 |
| Solubility | Soluble in DMSO |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 3-methoxypropanoic acid |
| InChI | InChI=1S/C4H8O3/c1-7-3-2-4(5)6/h2-3H2,1H3,(H,5,6) |
| InChIKey | YSIKHBWUBSFBRZ-UHFFFAOYSA-N |
| SMILES | COCCC(O)=O |
| Reference | 1: Brown A, Patel S, Ward C, Lorenz A, Ortiz M, DuRoss A, Wieghardt F, Esch A, Otten EG, Heiser LM, Korolchuk VI, Sun C, Sarkar S, Sahay G. PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Sci Rep. 2016 Aug 30;6:31750. doi: 10.1038/srep31750. PubMed PMID: 27572704; PubMed Central PMCID: PMC5004151. |
