m-PEG1-acid

  • CAT Number: I032729
  • CAS Number: 2544-06-1
  • Molecular Formula: C4H8O3
  • Molecular Weight: 104.11
  • Purity: 95%
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m-PEG1-acid (CAT: I032729) is a polyethylene glycol (PEG) derivative that features a terminal carboxylic acid group. This PEG derivative offers versatility in bioconjugation and drug delivery applications. The terminal carboxylic acid group can react with primary amine groups in the presence of activators like EDC (N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide) or DCC (N,N’-Dicyclohexylcarbodiimide) to form stable amide bonds. The hydrophilic PEG spacer enhances solubility in aqueous media, making m-PEG1-acid suitable for use in aqueous-based formulations.

Catalog Number I032729
CAS Number 2544-06-1
Synonyms

m-PEG1-acid

Molecular Formula

C4H8O3

Purity 95
Solubility Soluble in DMSO
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 3-methoxypropanoic acid
InChI InChI=1S/C4H8O3/c1-7-3-2-4(5)6/h2-3H2,1H3,(H,5,6)
InChIKey YSIKHBWUBSFBRZ-UHFFFAOYSA-N
SMILES COCCC(O)=O
Reference

1: Brown A, Patel S, Ward C, Lorenz A, Ortiz M, DuRoss A, Wieghardt F, Esch A, Otten EG, Heiser LM, Korolchuk VI, Sun C, Sarkar S, Sahay G. PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Sci Rep. 2016 Aug 30;6:31750. doi: 10.1038/srep31750. PubMed PMID: 27572704; PubMed Central PMCID: PMC5004151.
2: Saifer MG, Williams LD, Sobczyk MA, Michaels SJ, Sherman MR. Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins. Mol Immunol. 2014 Feb;57(2):236-46. doi: 10.1016/j.molimm.2013.07.014. Epub 2013 Nov 5. PubMed PMID: 24200843.
3: Garay RP, El-Gewely R, Armstrong JK, Garratty G, Richette P. Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents. Expert Opin Drug Deliv. 2012 Nov;9(11):1319-23. doi: 10.1517/17425247.2012.720969. Epub 2012 Aug 30. PubMed PMID: 22931049.

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