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Nucleozin

Nucleozin

  • CAT Number: I003235
  • CAS Number: 341001-38-5
  • Molecular Formula: C21H19ClN4O4
  • Molecular Weight: 426.86
  • Purity: ≥95%
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<p style=/line-height:25px/>Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication.<br>IC50 Value:<br>Target: Influenza Virus NP<br>Nucleozin targets influenza A nucleoprotein, a multifunctional, RNA-binding protein necessary for virus replication. It induces the formation of nucleoptotein aggregates and inhibits its accumulation, interfering with viral replication. EC50 is in the nM range. Nucleozin is effective in H1N1, H3N2, and H5N1 flu virus strains.<br></p>

Catalog Number I003235
CAS Number 341001-38-5
Molecular Formula

C21H19ClN4O4

Purity 95%
Target NA
Solubility DMSO
Storage Store at -20°C
InChI InChI=1S/C21H19ClN4O4/c1-14-19(20(23-30-14)15-5-3-2-4-6-15)21(27)25-11-9-24(10-12-25)18-8-7-16(26(28)29)13-17(18)22/h2-8,13H,9-12H2,1H3
InChIKey OWXBJAPOSQSWAO-UHFFFAOYSA-N
SMILES O=C(N1CCN(C2=CC=C([N+]([O-])=O)C=C2Cl)CC1)C3=C(C)ON=C3C4=CC=CC=C4
Reference

</br>1:Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites. Pang B, Cheung NN, Zhang W, Dai J, Kao RY, Zhang H, Hao Q.Sci Rep. 2016 Jul 11;6:29684. doi: 10.1038/srep29684. PMID: 27404920 Free PMC Article</br>2:Nucleozin targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection. Amorim MJ, Kao RY, Digard P.J Virol. 2013 Apr;87(8):4694-703. doi: 10.1128/JVI.03123-12. Epub 2013 Feb 13. PMID: 23408618 Free PMC Article

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