LYN-1604 dihydrochloride

• CAT Number: I015600
• CAS Number: 2310109-38-5
• Molecular Formula: C₃₃H₄₅Cl₄N₃O₂
• Molecular Weight: 657.54
• Purity: ≥95%

LYN-1604 dihydrochloride (CAT: I015600) is a potent activator of UNC-51-like kinase 1 (ULK1) with potential applications in the research of triple-negative breast cancer (TNBC). LYN-1604 activates ULK1, exhibiting enzymatic activity and affinity for wild-type ULK1. It induces cell death, up-regulates Beclin-1, and promotes autophagy through the ULK complex in MDA-MB-231 cells. LYN-1604 also increases the cleavage of caspase 3, leading to apoptosis. In preclinical models of TNBC xenografts, LYN-1604 inhibits tumor growth by targeting ULK1-mediated cell death. These findings suggest LYN-1604 is a promising compound for further investigation in TNBC therapy.

Reference

[1]. Zhang L, et al. Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem Sci. 2017 Apr 1;8(4):2687-2701.