LY3295668

• CAT Number: I031229
• CAS Number: 1919888-06-4
• Molecular Formula: C24H26ClF2N5O2
• Molecular Weight: 489.95
• Purity: 98%
• Synonyms: LY3295668, LY-3295668, LY 3295668; AK-01; AK 01; AK01
• Solubility: Soluble in DMSO
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (2R,4R)-1-(3-chloro-2-fluorobenzyl)-4-((3-fluoro-6-((5-methyl-1H-pyrazol-3-yl)amino)pyridin-2-yl)methyl)-2-methylpiperidine-4-carboxylic acid
• InChI: InChI=1S/C24H26ClF2N5O2/c1-14-10-21(31-30-14)29-20-7-6-18(26)19(28-20)12-24(23(33)34)8-9-32(15(2)11-24)13-16-4-3-5-17(25)22(16)27/h3-7,10,15H,8-9,11-13H2,1-2H3,(H,33,34)(H2,28,29,30,31)/t15-,24-/m1/s1
• InChIKey: YQQZZYYQTCPEAS-OYLFLEFRSA-N
• SMILES: ClC1=CC=CC(CN2CC[C@](C(O)=O)(CC3=C(F)C=CC(NC4=NNC(C)=C4)=N3)C[C@H]2C)=C1F

LY3295668 (Cat.No:I031229) is a novel small molecule inhibitor with potential therapeutic applications in oncology. It selectively targets the bromodomain and extra-terminal (BET) proteins, which play a crucial role in gene regulation and cancer progression. By inhibiting BET proteins, LY3295668 can disrupt aberrant gene expression patterns and potentially suppress tumor growth. Preclinical studies are ongoing to evaluate its efficacy and safety in cancer treatment.

Reference

1: Gong X, Du J, Parsons SH, Merzoug FF, Webster Y, Iversen PW, Chio LC, Van Horn RD, Lin X, Blosser W, Han B, Jin S, Yao S, Bian H, Ficklin C, Fan L, Kapoor A, Antonysamy S, Mc Nulty AM, Froning K, Manglicmot D, Pustilnik A, Weichert K, Wasserman SR, Dowless M, Marugán C, Baquero C, Lallena MJ, Eastman SW, Hui YH, Dieter MZ, Doman T, Chu S, Qian HR, Ye XS, Barda DA, Plowman GD, Reinhard C, Campbell RM, Henry JR, Buchanan SG. Aurora-A kinase inhibition is synthetic lethal with loss of the RB1 tumor suppressor gene. Cancer Discov. 2018 Oct 29. pii: CD-18-0469. doi: 10.1158/2159-8290.CD-18-0469. [Epub ahead of print] PubMed PMID: 30373917.