LY2955303

• CAT Number: I007826
• CAS Number: 1433497-19-8
• Molecular Formula: C36H42N4O3
• Molecular Weight: 578.75
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: 2-8°C
• IUPAC Name: 4-[5-(3,5-ditert-butylphenyl)-1-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyrazol-3-yl]benzoic acid
• InChI: InChI=1S/C36H42N4O3/c1-35(2,3)28-20-27(21-29(22-28)36(4,5)6)32-23-31(24-8-10-26(11-9-24)34(42)43)37-40(32)30-14-12-25(13-15-30)33(41)39-18-16-38(7)17-19-39/h8-15,20-23H,16-19H2,1-7H3,(H,42,43)
• InChIKey: YVXYHNKIOFSFMZ-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=CC(=CC(=C1)C2=CC(=NN2C3=CC=C(C=C3)C(=O)N4CCN(CC4)C)C5=CC=C(C=C5)C(=O)O)C(C)(C)C

LY2955303 (Cat No.: I007826) is a highly potent and selective antagonist of the retinoic acid receptor gamma (RARγ) with a remarkable Ki value of 1.09 nM. This compound’s specificity for RARγ makes it a valuable tool in research related to retinoic acid signaling pathways and their impact on various cellular processes. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design In Press, Accepted Manuscript, Available online 20 May 2016 Norman E. Hughes, Thomas J. Bleisch, Scott A. Jones, Timothy I. Richardson, Robert A. Doti, Yong Wang, Stephanie L. Stout, Gregory L. Durst, Mark G. Chambers, Jennifer L. Oskins, Chaohua Lin, Lisa A. Adams, Todd J. Page, Robert J. Barr, Richard W. Zink, Harold Osborne, Chahrzad Montrose-Rafizadeh, Bryan H. Norman