For research use only. Not for therapeutic Use.
LY2880070(CAT: I040618) is an orally bioavailable small-molecule inhibitor of fibroblast growth factor receptors (FGFR) 1, 2, and 3, with selective activity designed to target dysregulated FGFR signaling in cancer. It demonstrates potent inhibition of FGFR-mediated cell proliferation and angiogenesis, particularly in tumor models harboring FGFR genetic alterations such as fusions or amplifications. LY2880070 is widely used in preclinical studies investigating FGFR-driven cancers, including bladder, endometrial, and cholangiocarcinoma. Its pharmacokinetic properties support sustained FGFR blockade, making it valuable for translational oncology research.
| CAS Number | 1375637-35-6 |
| Synonyms | N-[5-(2-methoxy-6-methylpyridin-3-yl)-1H-pyrazol-3-yl]-6-[(3R)-piperidin-3-yl]oxypyrazin-2-amine |
| Molecular Formula | C19H23N7O2 |
| Purity | ≥95% |
| IUPAC Name | N-[5-(2-methoxy-6-methylpyridin-3-yl)-1H-pyrazol-3-yl]-6-[(3R)-piperidin-3-yl]oxypyrazin-2-amine |
| InChI | InChI=1S/C19H23N7O2/c1-12-5-6-14(19(22-12)27-2)15-8-16(26-25-15)23-17-10-21-11-18(24-17)28-13-4-3-7-20-9-13/h5-6,8,10-11,13,20H,3-4,7,9H2,1-2H3,(H2,23,24,25,26)/t13-/m1/s1 |
| InChIKey | LAEFIEWPUJMANC-CYBMUJFWSA-N |
| SMILES | CC1=NC(=C(C=C1)C2=CC(=NN2)NC3=CN=CC(=N3)OC4CCCNC4)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
