AZ304

• CAT Number: I019444
• CAS Number: 942507-42-8
• Molecular Formula: C₂₇H₂₅N₅O₂
• Molecular Weight: 451.52
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 3-(2-cyanopropan-2-yl)-N-[3-[(7-methoxyquinazolin-4-yl)amino]-4-methylphenyl]benzamide
• InChI: InChI=1S/C27H25N5O2/c1-17-8-9-20(31-26(33)18-6-5-7-19(12-18)27(2,3)15-28)13-23(17)32-25-22-11-10-21(34-4)14-24(22)29-16-30-25/h5-14,16H,1-4H3,(H,31,33)(H,29,30,32)
• InChIKey: NGWQZRWVYYFTHC-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=NC=NC4=C3C=CC(=C4)OC

AZ304（Cat No.:I019444） is a synthetic inhibitor that specifically targets both wild-type and V600E mutant forms of BRAF, with respective IC50 values of 79 nM and 38 nM. Additionally, it exhibits inhibitory activity against CRAF, p38, and CSF1R, with IC50 values below 100 nM. By selectively inhibiting these kinases, AZ304 has the potential to disrupt signaling pathways involved in cell growth and proliferation, making it a promising candidate for the treatment of diseases associated with dysregulated BRAF signaling, such as certain types of cancer.

Reference

[1]. Ma R, et al. AZ304, a novel dual BRAF inhibitor, exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status. Br J Cancer. 2018 May;118(11):1453-1463.