LY2183240

• CAT Number: I005269
• CAS Number: 874902-19-9
• Molecular Formula: C17H17N5O
• Molecular Weight: 307.4
• Purity: ≥95%
• Target: FAAH
• Solubility: DMSO >10 mg/mL
• Storage: Store at -20°C
• IC50: 270 pM (anandamide uptake); 12.4 nM (FAAH)
• InChIKey: GZNIYOXWFCDBBJ-UHFFFAOYSA-N

LY2183240 (Cat.No:I005269) is a potent and selective inhibitor of phosphodiesterase 4 (PDE4). It is a small molecule drug that has been investigated for its potential in treating inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). LY2183240 works by inhibiting the enzyme PDE4, leading to increased intracellular levels of cyclic adenosine monophosphate (cAMP), which helps to reduce inflammation in the lungs.

Reference

1:Effects of the novel endocannabinoid uptake inhibitor, LY2183240, on fear-potentiated startle and alcohol-seeking behaviors in mice selectively bred for high alcohol preference. Powers MS, Barrenha GD, Mlinac NS, Barker EL, Chester JA.Psychopharmacology (Berl). 2010 Dec;212(4):571-83. doi: 10.1007/s00213-010-1997-2. Epub 2010 Sep 14. PMID: 20838777 Free PMC Article2:The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. Alexander JP, Cravatt BF.J Am Chem Soc. 2006 Aug 2;128(30):9699-704. PMID: 16866524