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LY-2835219

LY-2835219

  • CAT Number: I000912
  • CAS Number: 1231930-82-7
  • Molecular Formula: C₂₇H₃₂F₂N₈.CH₄O₃S
  • Molecular Weight: 602.7
  • Purity: ≥95%
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LY-2835219 (Cat.No:I000912) is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6) and is being studied for its potential in cancer treatment.

Catalog Number I000912
CAS Number 1231930-82-7
Molecular Formula

C₂₇H₃₂F₂N₈.CH₄O₃S

Purity 95%
Target Cyclin-Dependent Kinases
Solubility DMSO:84 mg/mL; Water:100 mg/mL
Storage 3 years -20℃ powder
IC50 2 nM(CDK4); 10 nM(CDK6)
IUPAC Name N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine;methanesulfonic acid
InChI InChI=1S/C27H32F2N8.CH4O3S/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26;1-5(2,3)4/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34);1H3,(H,2,3,4)
InChIKey NCJPFQPEVDHJAZ-UHFFFAOYSA-N
SMILES CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O
Reference

<p style=/line-height:25px/>
<br>[1]. Patrick J. Roberts, John E. Bisi, Jay C. Strum, et al. Two trials of other CDK4/6 inhibitors (NVP-LEE011 and LY2835219) have begun enrolling cancer patients for phase I clinical testing. JNCI J Natl Cancer Inst (2012) 104 (6): 476-487.
<br>[2]. CDK4/6 dual inhibitor LY2835219
<br>[3]. A Phase 1 Study of LY2835219 In Participants With Advanced Cancer
<br>[4]. Study of LY2835219 for Mantle Cell Lymphoma
</p>

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