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LXH254 free base

LXH254 free base

  • CAT Number: I031195
  • CAS Number: 1800398-38-2
  • Molecular Formula: C25H25F3N4O4
  • Molecular Weight: 502.49
  • Purity: 98%
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Naporafenib ( LXH254 ) is a type II ATP competitive inhibitor that inhibits the kinase activity of BRAF and CRAF with high selectivity. In a tumor model with BRAFV600 mutation, LXH254 not only inhibits MAPK signaling activity, but also inhibits mutant N- and KRAS-driven signals. LXH254 has oral bioavailability. In a variety of cell lines and xenograft models derived from human primary tumors, LXH254 can cause tumor regression.

Catalog Number I031195
CAS Number 1800398-38-2
Synonyms

LXH254; LXH-254; LXH 254; LXH254 free base; Naporafenib

Molecular Formula

C25H25F3N4O4

Purity 98
Solubility Soluble in DMSO
Storage Store at -20°C
IUPAC Name N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide
InChI InChI=1S/C25H25F3N4O4/c1-16-2-3-19(30-24(34)17-4-5-29-21(12-17)25(26,27)28)15-20(16)18-13-22(32-6-9-35-10-7-32)31-23(14-18)36-11-8-33/h2-5,12-15,33H,6-11H2,1H3,(H,30,34)
InChIKey UEPXBTCUIIGYCY-UHFFFAOYSA-N
SMILES O=C(C1=CC(C(F)(F)F)=NC=C1)NC2=CC=C(C)C(C3=CC(OCCO)=NC(N4CCOCC4)=C3)=C2
Reference

[1] Darrin D. Stuart, et al. AACR Cancer Res. 2018, 78(13 Sup

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