LXE408

• CAT Number: I031194
• CAS Number: 1799330-15-6
• Molecular Formula: C23H18FN7O2
• Molecular Weight: 443.44
• Purity: 98%
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-(4-fluoro-3-(6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl)-2,4-dimethyloxazole-5-carboxamide
• InChI: InChI=1S/C23H18FN7O2/c1-12-5-4-8-25-19(12)15-10-26-23-29-21(30-31(23)11-15)17-9-16(6-7-18(17)24)28-22(32)20-13(2)27-14(3)33-20/h4-11H,1-3H3,(H,28,32)
• InChIKey: GNVVPYCWVLCWKV-UHFFFAOYSA-N
• SMILES: O=C(C1=C(C)N=C(C)O1)NC2=CC=C(F)C(C3=NN4C=C(C5=NC=CC=C5C)C=NC4=N3)=C2

LXE408 (Cat No.:I031194) is a small molecule inhibitor that targets ATP-citrate lyase, an enzyme involved in the biosynthesis of fatty acids and cholesterol. It has potential therapeutic applications for nonalcoholic fatty liver disease and certain types of cancer, including ovarian and pancreatic cancer. LXE408 reduces intracellular cholesterol and fatty acid levels and lipid droplet accumulation in cells.

Reference

1: Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, Sciotti RJ, Pybus B, Kreishman-Deitrick M, Bursulaya B, Lai YH, Gao MY, Liang F, Mathison CJN, Liu X, Yeh V, Smith J, Lerario I, Xie Y, Chianelli D, Gibney M, Berman A, Chen YL, Jiricek J, Davis LC, Liu X, Ballard J, Khare S, Eggimann FK, Luneau A, Groessl T, Shapiro M, Richmond W, Johnson K, Rudewicz PJ, Rao SPS, Thompson C, Tuntland T, Spraggon G, Glynne RJ, Supek F, Wiesmann C, Molteni V. Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases. J Med Chem. 2020 Jul 29. doi: 10.1021/acs.jmedchem.0c00499. Epub ahead of print. PMID: 32667203.