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<span style="color:#000000;">1. Australas Psychiatry. 2016 Jun;24(3):289-91. doi: 10.1177/1039856216641309. Epub </span></div>
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<span style="color:#000000;">2016 Apr 1.Lurasidone: an antipsychotic with antidepressant effects in bipolar depression?Keks NA(1), Hope J(2), Castle D(3).</span></div>
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<span style="color:#000000;">OBJECTIVE: Lurasidone is a new serotonin-dopamine antagonist atypical antipsychotic which also appears to be effective in bipolar depression. This paper will briefly review the evidence concerning lurasidone.</span></div>
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<span style="color:#000000;">CONCLUSIONS: Lurasidone is an antagonist at dopamine D2, serotonin 5-HT2 and 5-HT7, and partial agonist at 5HT1a receptors; it has no anticholinergic or antihistaminic activity. Rapidly absorbed, it has a half-life of 18 ± 7 hours, will reach steady state in five days and is taken at night with food (absorption is halved on an empty stomach). It is hepatically metabolised with some potential for interactions. Lurasidone is an effective antipsychotic in acute schizophrenia, and non-inferior to quetiapine but not risperidone in 12-month studies. Lurasidone may cause mild sedation, nausea, agitation, insomnia and akathisia (especially at initiation). Risks for weight gain, hyperprolactinaemia and QTc prolongation are low. Lurasidone has demonstrated antidepressant efficacy both as monotherapy and in addition to lithium or valproate in bipolar depression, of a comparable degree to that seen with the combination of olanzapine and fluoxetine. Lurasidone appears to be a "metabolically-friendly" antipsychotic for schizophrenia where weight gain and hyperprolactinaemia are of concern, and may also prove useful in bipolar depression (although not approved for this condition in Australia).</span></div>
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<span style="color:#000000;">2. Biomed Res Int. 2017;2017:3084859. doi: 10.1155/2017/3084859. Epub 2017 May 9.Lurasidone in the Treatment of Bipolar Depression: Systematic Review of Systematic Reviews.Fornaro M(1)(2), De Berardis D(3), Perna G(4)(5)(6), Solmi M(7)(8), Veronese </span></div>
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<span style="color:#000000;">N(8)(9), Orsolini L(10), Buonaguro EF(2), Iasevoli F(1), Köhler CA(11), Carvalho </span></div>
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<span style="color:#000000;">AF(11), de Bartolomeis A(1).</span></div>
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<span style="color:#000000;">INTRODUCTION: A burgeoning number of systematic reviews considering lurasidone in the treatment of bipolar depression have occurred since its Food and Drug Administration extended approval in 2013. While a paucity of available quantitative evidence still precludes preliminary meta-analysis on the matter, the present quality assessment of systematic review of systematic reviews, nonetheless, aims at highlighting currentessential information on the topic.</span></div>
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<span style="color:#000000;">METHODS: Both published and unpublished systematic reviews about lurasidone mono- or adjunctive therapy in the treatment of bipolar depression were searched by two independent authors inquiring PubMed/Cochrane/Embase/Scopus from inception until October 2016.</span></div>
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<span style="color:#000000;">RESULTS: Twelve included systematic reviews were of moderate-to-high quality andconsistent in covering the handful of RCTs available to date, suggesting the promising efficacy, safety, and tolerability profile of lurasidone. Concordance on the drug profile seems to be corroborated by a steadily increasing number of convergent qualitative reports on the matter.</span></div>
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<span style="color:#000000;">LIMITATIONS: Publication, sponsorship, language, citation, and measurement biases.</span></div>
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<span style="color:#000000;">ONCLUSIONS: Despite being preliminary in nature, this overview stipulates the effectiveness of lurasidone in the acute treatment of Type I bipolar depression overall. As outlined by most of the reviewed evidence, recommendations for future research should include further controlled trials of extended duration.</span></div>
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<span style="font-family: arial, helvetica, sans-serif;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/20404009" rel="nofollow" style="margin: 0px; padding: 0px; background-color: transparent; text-decoration: none; color: rgb(0, 118, 223);" target="_blank"><span style="color: rgb(0, 0, 0);">3.Ishibashi T, et al. J Pharmacol Exp Ther, 2010, 334(1), 171-181.</span></a></span></li>
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<span style="font-family: arial, helvetica, sans-serif;"><span style="margin: 0px; padding: 0px; background-color: transparent;">4</span><span style="margin: 0px; padding: 0px; background-color: transparent;">.<a href="http://www.ncbi.nlm.nih.gov/pubmed/17662268" rel="nofollow" style="margin: 0px; padding: 0px; background-color: transparent; text-decoration: none; color: rgb(0, 118, 223);" target="_blank"><span style="color: rgb(0, 0, 0);">Ishiyama T, et al. Eur J Pharmacol, 2007, 572(2-3), 160-170.</span></a></span></span></li>
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<span style="font-family: arial, helvetica, sans-serif;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/17881065" rel="nofollow" style="margin: 0px; padding: 0px; background-color: transparent; text-decoration: none; color: rgb(0, 118, 223);" target="_blank"><span style="color: rgb(0, 0, 0);">5. Enomoto T, et al. Behav Brain Res, 2008, 186(2), 197-207.</span></a></span></li>
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<span style="font-family: arial, helvetica, sans-serif;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/21349227" rel="nofollow" style="margin: 0px; padding: 0px; background-color: transparent; text-decoration: none; color: rgb(0, 118, 223);" target="_blank"><span style="color: rgb(0, 0, 0);">6.Fumagalli F, et al. Int J Neuropsychopharmacol, 2012, 15(2), 235-246.</span></a></span></li>
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