For research use only. Not for therapeutic Use.
LTA4H-IN-1（Cat No.:I031274）is a potent, selective inhibitor of leukotriene A4 hydrolase (LTA4H), an enzyme responsible for converting leukotriene A4 into pro-inflammatory leukotriene B4 (LTB4). By blocking LTA4H activity, LTA4H-IN-1 reduces LTB4-mediated neutrophil recruitment and inflammation, making it a valuable therapeutic candidate for inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and arthritis. It offers a targeted approach to modulating the leukotriene pathway without affecting other eicosanoids. LTA4H-IN-1 is primarily used in preclinical research to explore anti-inflammatory strategies and the role of LTB4 in disease progression.
| CAS Number | 1799681-85-8 |
| Synonyms | (3S)-3-amino-4-[5-[4-(5-chloro-3-fluoropyridin-2-yl)oxyphenyl]tetrazol-2-yl]butanoic acid |
| Molecular Formula | C16H14ClFN6O3 |
| Purity | ≥95% |
| IUPAC Name | (3S)-3-amino-4-[5-[4-(5-chloro-3-fluoropyridin-2-yl)oxyphenyl]tetrazol-2-yl]butanoic acid |
| InChI | InChI=1S/C16H14ClFN6O3/c17-10-5-13(18)16(20-7-10)27-12-3-1-9(2-4-12)15-21-23-24(22-15)8-11(19)6-14(25)26/h1-5,7,11H,6,8,19H2,(H,25,26)/t11-/m0/s1 |
| InChIKey | ZEGMEJVULDALSH-NSHDSACASA-N |
| SMILES | C1=CC(=CC=C1C2=NN(N=N2)C[C@H](CC(=O)O)N)OC3=C(C=C(C=N3)Cl)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
