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Lonidamine

Lonidamine

  • CAT Number: A000299
  • CAS Number: 50264-69-2
  • Molecular Formula: C₁₅H₁₀Cl₂N₂O₂
  • Molecular Weight: 321.16
  • Purity: ≥95%
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Lonidamine(cas 50264-69-2) is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase. Later studies in Ehrlich ascites tumor cells showed that lonidamine inhibits both respiration and glycolysis leading to a decrease in cellular ATP.

Catalog Number A000299
CAS Number 50264-69-2
Molecular Formula

C₁₅H₁₀Cl₂N₂O₂

Purity 95%
Target hexokinase
Storage 3 years -20C powder
InChI InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21)
InChIKey WDRYRZXSPDWGEB-UHFFFAOYSA-N
SMILES C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O

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