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LSN 3213128

LSN 3213128

  • CAT Number: I018509
  • CAS Number: 1941211-99-9
  • Molecular Formula: C₁₇H₁₆FN₃O₄S₂
  • Molecular Weight: 409.46
  • Purity: ≥95%
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LSN 3213128  (Cat.No:I018509) is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity[1].

Catalog Number I018509
CAS Number 1941211-99-9
Molecular Formula

C₁₇H₁₆FN₃O₄S₂

Purity 95%
Reference

[1]. Fales KR, et al. Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. J Med Chem. 2017 Dec 14;60(23):9599-9616.

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