LP-211

• CAT Number: I007712
• CAS Number: 1052147-86-0
• Molecular Formula: C30H34N4O
• Molecular Weight: 466.629
• Purity: ≥95%
• Target: 5-HT7 receptor Agonist
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term , or -20°C for long term.
• IUPAC Name: N-[(4-cyanophenyl)methyl]-6-[4-(2-phenylphenyl)piperazin-1-yl]hexanamide
• InChI: InChI=1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35)
• InChIKey: BQEDZLDNNBDKDS-UHFFFAOYSA-N
• SMILES: C1CN(CCN1CCCCCC(=O)NCC2=CC=C(C=C2)C#N)C3=CC=CC=C3C4=CC=CC=C4

LP-211 (Cat.No:I007712) is a selective agonist of the serotonin 5-HT7 receptor. It has been studied for its potential therapeutic applications in various neurological and psychiatric disorders. LP-211 has shown promise in preclinical models for the treatment of depression, anxiety, and cognitive impairments. Further research is underway to explore its therapeutic potential.

Reference

1:Retraction note: Serotonin 5-HT7 receptor agonist, LP-211, exacerbates Na+, K+-ATPase/Mg2+ ATPase imbalances in spinal cord-injured male rats. Norouzi-Javidan A, Javanbakht J, Barati F, Fakhraei N, Mohammadi F, Dehpour AR.Diagn Pathol. 2016 Nov 2;11(1):108. No abstract available. PMID: 27802823 Free PMC Article2:Effect of 5-HT7 receptor agonist, LP-211, on micturition following spinal cord injury in male rats. Norouzi-Javidan A, Javanbakht J, Barati F, Fakhraei N, Mohammadi F, Dehpour AR.Am J Transl Res. 2016 Jun 15;8(6):2525-33. eCollection 2016. PMID: 27398137 Free PMC Article3:Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice. Demirkaya K, Akgün ÖM, Şenel B, Öncel Torun Z, Seyrek M, Lacivita E, Leopoldo M, Doğrul A.J Appl Oral Sci. 2016 May-Jun;24(3):218-22. doi: 10.1590/1678-775720150563. PMID: 27383702 Free PMC Article4:Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. Lacivita E, Podlewska S, Speranza L, Niso M, Satała G, Perrone R, Perrone-Capano C, Bojarski AJ, Leopoldo M.Eur J Med Chem. 2016 Sep 14;120:363-79. doi: 10.1016/j.ejmech.2016.05.005. Epub 2016 May 6. PMID: 27318552 5:Serotonin 5-HT7 receptor agonist, LP-211, exacerbates Na(+), K(+)-ATPase/Mg(2+)-ATPase imbalances in spinal cord-injured male rats. Norouzi-Javidan A, Javanbakht J, Barati F, Fakhraei N, Mohammadi F, Dehpour AR.Diagn Pathol. 2015 Sep 14;10:157. doi: 10.1186/s13000-015-0397-7. Retraction in: Diagn Pathol. 2016 Nov 2;11(1):108. PMID: 26369408 Free PMC Article6:Prepuberal stimulation of 5-HT7-R by LP-211 in a rat model of hyper-activity and attention-deficit: permanent effects on attention, brain amino acids and synaptic markers in the fronto-striatal interface. Ruocco LA, Treno C, Gironi Carnevale UA, Arra C, Boatto G, Nieddu M, Pagano C, Illiano P, Barbato F, Tino A, Carboni E, Laviola G, Lacivita E, Leopoldo M, Adriani W, Sadile AG.PLoS One. 2014 Apr 7;9(4):e83003. doi: 10.1371/journal.pone.0083003. eCollection 2014. PMID: 24709857 Free PMC Article7:Systemic administration and local microinjection into the central nervous system of the 5-HT(7) receptor agonist LP-211 modify the sleep-wake cycle in the rat. Monti JM, Leopoldo M, Jantos H.Behav Brain Res. 2014 Feb 1;259:321-9. doi: 10.1016/j.bbr.2013.11.030. Epub 2013 Nov 25. PMID: 24286819 8:LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor. Hedlund PB, Leopoldo M, Caccia S, Sarkisyan G, Fracasso C, Martelli G, Lacivita E, Berardi F, Perrone R.Neurosci Lett. 2010 Aug 30;481(1):12-6. doi: 10.1016/j.neulet.2010.06.036. Epub 2010 Jun 23. PMID: 20600619 Free PMC Article