LOX-IN-3

• CAT Number: I026613
• CAS Number: 2409963-83-1
• Molecular Formula: C13H13FN2O2S
• Molecular Weight: 280.32
• Purity: ≥95%
• Synonyms: (Z)-3-fluoro-4-quinolin-8-ylsulfonylbut-2-en-1-amine
• InChI: InChI=1S/C13H13FN2O2S/c14-11(6-7-15)9-19(17,18)12-5-1-3-10-4-2-8-16-13(10)12/h1-6,8H,7,9,15H2/b11-6-
• InChIKey: DHXXLGDTPFPYRH-WDZFZDKYSA-N
• SMILES: C1=CC2=C(C(=C1)S(=O)(=O)C/C(=C/CN)/F)N=CC=C2

LOX-IN-3（Cat No.:I026613）is a potent, selective inhibitor of lysyl oxidase (LOX), an enzyme responsible for catalyzing the cross-linking of collagen and elastin in the extracellular matrix. By targeting LOX, LOX-IN-3 disrupts extracellular matrix stiffening, a process closely associated with tumor progression, metastasis, and fibrotic diseases. It has shown significant efficacy in preclinical models, reducing fibrosis and inhibiting tumor invasiveness. LOX-IN-3 serves as a valuable tool for studying LOX-mediated pathologies and exploring therapeutic strategies against cancer, pulmonary fibrosis, and other conditions involving abnormal tissue remodeling and extracellular matrix dynamics.