Lornoxicam

  • CAT Number: A000419
  • CAS Number: 70374-39-9
  • Molecular Formula: C13H10ClN3O4S2
  • Molecular Weight: 371.8
  • Purity: ≥95%
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Lornoxicam is a new nonsteroidal anti-inflammatory drug of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug.

Catalog Number A000419
CAS Number 70374-39-9
Molecular Formula

C13H10ClN3O4S2

Purity 95%
Target COX
Solubility Limited solubility
Storage -20°C
InChI 1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)
InChIKey WLHQHAUOOXYABV-UHFFFAOYSA-N
SMILES CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3
Reference

1: Joshny J, Vedha Hari BN, Ramya Devi D. Experimental optimization of Lornoxicam
liposomes for sustained topical delivery. Eur J Pharm Sci. 2017 Oct 27. pii:
S0928-0987(17)30587-0. doi: 10.1016/j.ejps.2017.10.032. [Epub ahead of print]
PubMed PMID: 29111151.
<br>

2: Helmy HS, El-Sahar AE, Sayed RH, Shamma RN, Salama AH, Elbaz EM. Therapeutic
effects of lornoxicam-loaded nanomicellar formula in experimental models of
rheumatoid arthritis. Int J Nanomedicine. 2017 Sep 22;12:7015-7023. doi:
10.2147/IJN.S147738. eCollection 2017. PubMed PMID: 29026298; PubMed Central
PMCID: PMC5626385.
<br>

3: Mustafa-Mikhail S, Assaraf S, Abecassis P, Dabaja H, Jarrous S, Hadad S,
Lowenstein L. Comparison between Lornoxicam and Paracetamol for Pain Management
after Dilation and Curettage for Abortion. Isr Med Assoc J. 2017
Sep;19(9):543-546. PubMed PMID: 28971636.
<br>

4: Dasgupta S, Ray S, Dey S, Pal P, Mazumder B. Transdermal Lipid Nanocarriers: A
Potential Delivery System for Lornoxicam. Pharm Nanotechnol. 2017;5(1):32-43.
doi: 10.2174/2211738505666170105161336. PubMed PMID: 28948909.
<br>

5: Jain AD, Vsm R, Ksn SB, Km S, Tewathia N. A Comparative Assessment of
Postoperative Analgesic Efficacy of Lornoxicam versus Tramadol after Open
Reduction and Internal Fixation of Mandibular Fractures. Craniomaxillofac Trauma
Reconstr. 2017 Sep;10(3):171-174. doi: 10.1055/s-0037-1600901. Epub 2017 Mar 22.
PubMed PMID: 28751939; PubMed Central PMCID: PMC5526686.
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6: Ba&#351;ak N, Aksoy Y, Kaydu A, &#350;ahin &#214;F. Lornoxicam use to reduce the pain
associated with propofol injection. Libyan J Med. 2017 Dec;12(1):1313093. doi:
10.1080/19932820.2017.1313093. PubMed PMID: 28449627; PubMed Central PMCID:
PMC5418937.
<br>

7: Moutasim MY, ElMeshad AN, El-Nabarawi MA. A pharmaceutical study on lornoxicam
fast disintegrating tablets: formulation and in vitro and in vivo evaluation.
Drug Deliv Transl Res. 2017 Jun;7(3):450-459. doi: 10.1007/s13346-017-0367-6.
PubMed PMID: 28283842.
<br>

8: El-Ridy MS, Yehia SA, Mohsen AM, El-Awdan SA, Darwish AB. Formulation of
Niosomal Gel for Enhanced Transdermal Lornoxicam Delivery: In-Vitro and In-Vivo
Evaluation. Curr Drug Deliv. 2017 Feb 24. doi: 10.2174/1567201814666170224141548.
[Epub ahead of print] PubMed PMID: 28240177.
<br>

9: Zaid AN, Mousa A, Jaradat N, Bustami R. Lornoxicam Immediate-Release Tablets:
Formulation and Bioequivalence Study in Healthy Mediterranean Volunteers Using a
Validated LC-MS/MS Method. Clin Pharmacol Drug Dev. 2017 Nov;6(6):564-569. doi:
10.1002/cpdd.333. Epub 2017 Feb 8. PubMed PMID: 28176487.

<br>
10: Sivgin V, Kucuk A, Comu FM, Kosem B, Kartal S, Turgut HC, Arpaci H, Aydin ME,
Koc DS, Ozer A, Arslan M, Alkan M. Effects of intravenous ibuprofen and
lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia
reperfusion injury. Bratisl Lek Listy. 2016;117(12):722-725. doi:
10.4149/BLL_2016_138. PubMed PMID: 28127969.

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