Loratadine

• CAT Number: A000505
• CAS Number: 79794-75-5
• Molecular Formula: C22H23ClN2O2
• Molecular Weight: 382.9
• Purity: 98%
• Target: Histamine Receptor
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• IUPAC Name: ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
• InChI: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
• InChIKey: JCCNYMKQOSZNPW-UHFFFAOYSA-N
• SMILES: CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1

Loratadine (CAT: A000505) is a selective histamine H1 receptor antagonist for the treatment of allergies. It is also a selective B (0) AT2 inhibitor with IC50 of 4 μ M. It is clinically used to relieve symptoms related to allergic rhinitis, such as sneezing, runny nose and nasal itching, as well as eye itching and burning. It is also used to relieve symptoms of chronic urticaria and other allergic skin diseases.

Overview of Clinical Research

Loratadine is a Histamine H1 receptor antagonist developed by the NovaDel Pharma.The Phase-II for Seasonal allergic rhinitis in USA (Transmucosal) was suspended in 2004.

Reference

1: Kay GG, Harris AG. Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation. Clin Exp Allergy. 1999 Jul;29 Suppl 3:147-50. Review. PubMed PMID: 10444229.
2: Monroe EW. Safety and efficacy of loratadine in urticaria. Int J Dermatol. 1996 Dec;35(12):837-41. Review. PubMed PMID: 8970837.
3: Clissold SP, Sorkin EM, Goa KL. Loratadine. A preliminary review of its pharmacodynamic properties and therapeutic efficacy. Drugs. 1989 Jan;37(1):42-57. Review. PubMed PMID: 2523301.