Lomustine

  • CAT Number: A001123
  • CAS Number: 13010-47-4
  • Molecular Formula: C9H16ClN3O2
  • Molecular Weight: 233.7
  • Purity: ≥95%
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Lomustine is a nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Catalog Number A001123
CAS Number 13010-47-4
Synonyms

c79037

Molecular Formula

C9H16ClN3O2

Purity 95%
Target DNA Alkylating
Solubility >11.7mg/mL in DMSO
Storage 3 years -20C powder
Reference

</br>1:Biomarker and Histopathology Evaluation of Patients with Recurrent Glioblastoma Treated with Galunisertib, Lomustine, or the Combination of Galunisertib and Lomustine. Capper D, von Deimling A, Brandes AA, Carpentier AF, Kesari S, Sepulveda-Sanchez JM, Wheeler HR, Chinot O, Cher L, Steinbach JP, Specenier P, Rodon J, Cleverly A, Smith C, Gueorguieva I, Miles C, Guba SC, Desaiah D, Estrem ST, Lahn MM, Wick W.Int J Mol Sci. 2017 May 6;18(5). pii: E995. doi: 10.3390/ijms18050995. PMID: 28481241 Free Article</br>2:Lomustine induced acute pulmonary toxicity in a pediatric medulloblastoma survivor. Radhakrishnan V, Perumal J, Sundersingh S, Sagar T.South Asian J Cancer. 2017 Jan-Mar;6(1):38-39. doi: 10.4103/2278-330X.202570. No abstract available. PMID: 28413799 Free PMC Article</br>3:Procarbazine, Lomustine, and Vincristine (PCV) Regimen for Central Nervous System Tumors. Solimando DA Jr, Waddell JA.Hosp Pharm. 2017 Feb;52(2):98-104. doi: 10.1310/hpj5202-98. PMID: 28321136 </br>4:Is CCNU (lomustine) valuable for treatment of cutaneous epitheliotropic lymphoma in dogs? A critically appraised topic. Laprais A, Olivry T.BMC Vet Res. 2017 Feb 21;13(1):61. doi: 10.1186/s12917-017-0978-7. Review. PMID: 28222789 Free PMC Article</br>5:Analysis of lomustine drug content in FDA-approved and compounded lomustine capsules. KuKanich B, Warner M, Hahn K.J Am Vet Med Assoc. 2017 Feb 1;250(3):322-326. doi: 10.2460/javma.250.3.322. PMID: 28117638 </br>6:Inhibition of histone deacetylases sensitizes glioblastoma cells to lomustine. Staberg M, Michaelsen SR, Rasmussen RD, Villingshøj M, Poulsen HS, Hamerlik P.Cell Oncol (Dordr). 2017 Feb;40(1):21-32. doi: 10.1007/s13402-016-0301-9. Epub 2016 Oct 20. PMID: 27766591 </br>7:A randomized phase II trial of standard dose bevacizumab versus low dose bevacizumab plus lomustine (CCNU) in adults with recurrent glioblastoma. Weathers SP, Han X, Liu DD, Conrad CA, Gilbert MR, Loghin ME, O/’Brien BJ, Penas-Prado M, Puduvalli VK, Tremont-Lukats I, Colen RR, Yung WKA, de Groot JF.J Neurooncol. 2016 Sep;129(3):487-494. doi: 10.1007/s11060-016-2195-9. Epub 2016 Jul 12. PMID: 27406589 Free PMC Article</br>8:A retrospective evaluation of lomustine (CeeNU) in 32 treatment naïve cats with intermediate to large cell gastrointestinal lymphoma (2006-2013). Rau SE, Burgess KE.Vet Comp Oncol. 2016 Jun 9. doi: 10.1111/vco.12243. [Epub ahead of print] PMID: 27277825 </br>9:Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. Yagiz K, Huang TT, Lopez Espinoza F, Mendoza D, Ibañez CE, Gruber HE, Jolly DJ, Robbins JM.Neuro Oncol. 2016 Oct;18(10):1390-401. doi: 10.1093/neuonc/now089. Epub 2016 May 10. PMID: 27166379 </br>10:Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats. Ishikawa M, Saito K, Yamada H, Nakatsu N, Maekawa K, Saito Y.Lipids Health Dis. 2016 Apr 12;15:74. doi: 10.1186/s12944-016-0244-1. PMID: 27068811 Free PMC Article

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