Lomefloxacin Hydrochloride

• CAT Number: A000853
• CAS Number: 98079-52-8
• Molecular Formula: C17H20ClF2N3O3
• Molecular Weight: 387.81
• Purity: ≥95%
• Storage: -20°C
• InChI: InChI=1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H
• InChIKey: KXEBLAPZMOQCKO-UHFFFAOYSA-N
• SMILES: CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl

Lomefloxacin is a fluoroquinolone antibiotic that is commonly used to treat bacterial infections, including bronchitis and urinary tract infections. It is used as a pre-operative prophylactic to prevent urinary tract infection caused by S. pneumoniae, E. coli, and K. pneumoniae. It is used to induce genomic instability in mice and modification of the kinetics of growth of Gram-negative bacteria.

Reference

1: Abdelbary A, Salem HF, Khallaf RA, Ali AM. Mucoadhesive niosomal in situ gel
for ocular tissue targeting: in vitro and in vivo evaluation of lomefloxacin
hydrochloride. Pharm Dev Technol. 2017 May;22(3):409-417. doi:
10.1080/10837450.2016.1219916. Epub 2016 Aug 31. PubMed PMID: 27476543.

2: Wei Y, Du S, Ito Y. Enantioseparation of lomefloxacin hydrochloride by
high-speed counter-current chromatography using sulfated-β-cyclodextrin as a
chiral selector. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct
15;878(28):2937-41. doi: 10.1016/j.jchromb.2010.08.030. Epub 2010 Sep 15. PubMed
PMID: 20837406; PubMed Central PMCID: PMC2950249.

3: Yasueda S, Higashiyama M, Yamaguchi M, Isowaki A, Ohtori A. Corneal critical
barrier against the penetration of dexamethasone and lomefloxacin hydrochloride:
evaluation by the activation energy for drug partition and diffusion in cornea.
Drug Dev Ind Pharm. 2007 Aug;33(8):805-11. PubMed PMID: 17729097.

4: Sultana N, Arayne MS, Furqan H. In vitro availability of lomefloxacin
hydrochloride in presence of essential and trace elements. Pak J Pharm Sci. 2005
Jul;18(3):59-65. PubMed PMID: 16380347.

5: Bai ZZ, Zhang QS, Sheng LS. [Study on photodegradation kinetics of
lomefloxacin hydrochloride aqueous solution]. Yao Xue Xue Bao. 2001
Mar;36(3):210-4. Chinese. PubMed PMID: 12580090.

6: Arata J, Horio T, Soejima R, Ohara K. Photosensitivity reactions caused by
lomefloxacin hydrochloride: a multicenter survey. Antimicrob Agents Chemother.
1998 Dec;42(12):3141-5. PubMed PMID: 9835505; PubMed Central PMCID: PMC106013.

7: Derevianko II, Lopatkin NA, Khodyreva LA, Kondrat/’eva EM. [The use of Maxaquin
(lomefloxacin hydrochloride) in the treatment of nonspecific inflammatory
diseases and in the prevention of surgical interventions in urology]. Urol Nefrol
(Mosk). 1998 Sep-Oct;(5):14-8. Russian. PubMed PMID: 9820038.

8: Kuznetsovoĭ SM. [Lomefloxacin hydrochloride (Maxaquin), a long-acting
fluoroquinolone (information for specialists)]. Antibiot Khimioter.
1998;43(2):40-1. Russian. PubMed PMID: 9551172.