LL Z1640-2

• CAT Number: R003072
• CAS Number: 253863-19-3
• Molecular Formula: C19H22O7
• Molecular Weight: 362.4
• Purity: ≥95%
• Synonyms: FR148083;L-783,279;LL-Z 1640-2
• Storage: 2-8°C
• IUPAC Name: (4S,6Z,9S,10S,12E)-9,10,18-trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione
• InChI: InChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1
• InChIKey: NEQZWEXWOFPKOT-BYRRXHGESA-N
• SMILES: CC1CC=CC(=O)C(C(CC=CC2=C(C(=CC(=C2)OC)O)C(=O)O1)O)O

5Z-7-Oxozeaneol（Cat No.:R003072） is a natural compound with antiprotozoal properties. It acts as a potent and irreversible inhibitor of TAK1 (transforming growth factor-beta-activated kinase 1) and VEGF-R2 (vascular endothelial growth factor receptor 2). It exhibits remarkable inhibitory activity against TAK1 and VEGF-R2, with IC50 values of 8 nM and 52 nM, respectively. TAK1 is involved in various cellular processes, including inflammation and cell survival, while VEGF-R2 plays a crucial role in angiogenesis. The selective inhibition of these targets by 5Z-7-Oxozeaneol suggests potential therapeutic applications in diseases related to these pathways.

Reference

New zearalenone related macrolides and isocoumarins from an unidentified fungus. Ellestad G. A. et al. , J. Org. Chem. 1978, 43, 2339.A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J. Ninomiya-Tsuji J. et al. , J. Biol. Chem. 2003, 278, 18485.